Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation

AbstractPurpose of ReviewThis review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses.Recent FindingsRecent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses.SummaryMast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research