Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report

Publication date: Available online 16 April 2018 Source:Case Reports in Women's Health Author(s): D. Franic, Z. Iternička, M. Franić-Ivanišević The use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus (LS) in a 38-year-old premenopausal woman is reported. The diagnosis was confirmed histologically and the symptoms documented using the ICIQ Vaginal Symptoms Questionnaire (ICIQ-VS) and the Female Sexual Function Index (FSFI) questionnaire. PRP was prepared from autologous blood using the Regen Cellular Matrix Kit. PRP was administered twice over two months. Histology at follow-up one month after the second administration showed the epidermis was nearly normal and upper dermal cellularity had been restored. The patient was symptom-free and both her ICIQ-VS and her FSFI scores had improved significantly. PRP is a potential new treatment option for LS which needs further assessment in randomized controlled trials.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research

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ConclusionAlthough debate still exists regarding the pathogenesis of LS, it is agreed that LS can pose a treatment challenge to physicians and surgeons. Treatment options for LS range from pharmacological to surgical, depending on severity and location of disease, patient factors, and response of previous treatments.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract BACKGROUND/OBJECTIVES: The Vulval disease Quality of Life Index (VQLI) is a new tool that assesses the burden of vulval disease on quality of life (QoL). Our objective was to assess the correlation between VQLI score and clinician-rated severity scores, overall patient itch/discomfort, disease duration, sexual activity, and age, in vulval lichen sclerosus (VLS) at a vulval disorders clinic. METHODS: A retrospective case note review, including consecutive women with VLS who attended the clinic between April and October 2018. Outcome measures include the VQLI score, clinician-rated severity score, and ...
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
The most problematic vulvovaginal conditions are familiar to dermatologists but may exhibit distinct clinical features or medication management due to the anatomic location. Part 2 of this CME will focus on management pearls for treating vulvar diseases. We highlight key conditions such as lichen sclerosus, erosive lichen planus, and vulvodynia. Additionally, we will review conditions that dermatologists may be less familiar with, such as plasma cell vulvitis, desquamative inflammatory vaginitis, vulvar aphthae, and low estrogen states.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
The purpose of the present systematic review is to evaluate the available medical treatments for vulvar lichen sclerosus, using an arm based network meta-analysis protocol.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Systematic Review Source Type: research
Condition:   Vulvar Lichen Sclerosus Intervention:   Device: The CO2RE® System Sponsor:   Candela Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Vulvar Lichen Sclerosus Intervention:   Device: The CO2RE® System Sponsor:   Candela Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Vulvar Lichen Sclerosus Intervention:   Device: The CO2RE® System Sponsor:   Candela Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Vulvar Lichen Sclerosus Intervention:   Device: The CO2RE® System Sponsor:   Candela Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Vulvar Lichen Sclerosus Intervention:   Device: The CO2RE® System Sponsor:   Candela Corporation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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