Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical-Computational Evaluation [Original Articles]

Conclusions:
Computer simulations revealed that intrinsic interventricular dyssynchrony is the dominant component of the electrical substrate driving the response to CRT. Intrinsic intraventricular dyssynchrony and any dyssynchrony during biventricular pacing play a minor role in this respect. This may facilitate patient-specific modeling for prediction of CRT response.

Clinical Trial Registration:
URL: https://www.clinicaltrials.gov. Unique identifier: NCT01270646.

Source: Circulation: Arrhythmia and Electrophysiology - April 13, 2018 Category: Cardiology Authors: Huntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., Prinzen, F. W., Delhaas, T., Lumens, J., Bordachar, P. Tags: Electrophysiology, Computational Biology, Heart Failure, Pacemaker Original Articles Source Type: research