Love Your Hair Color? You Have 100 Genes to Thank

The researchers who pinpointed the origins of hair hue said their findings could improve understanding of health conditions linked to pigmentation, including skin, testicular, prostate and ovarian cancers.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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In conclusion, Elk1 inhibition induced thyroid cancer cell apoptosis and restrained their proliferation by regulating Egr‑1/PTEN, indicating a potential role for Elk1 in thyroid cancer treatment. PMID: 30015900 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Jiang C, Qu X, Ke H, Gong W, Chen R, Yang W, Cheng Z Abstract In the present study, the expression levels of high‑mobility group protein B1 (HMGB1), Toll‑like receptor 4 (TLR4), nuclear factor (NF)‑κB and tumor necrosis factor (TNF)‑α in malignant epithelial ovarian cancer (MEOC) were investigated in regards to several clinicopathological characteristics. A total of 20 patients with MEOC who underwent surgery were recruited in the present study. The mRNA and protein expression of HMGB1, TLR4, NF‑κB and TNF‑α was determined in patients with MEOC and compared wit...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA‑665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10. Mol Med Rep. 2018 Jul 05;: Authors: Liu J, Jiang Y, Wan Y, Zhou S, Thapa S, Cheng W Abstract Ovarian cancer is the most lethal gynecological cancer and its metastasis leads to a poor prognosis. The present study was designed to elucidate how microRNA (miR)‑665 regulates the proliferation and migration of ovarian tumor cells. Reverse transcription‑polymerase chain reaction (RT‑PCR) demonstrated that miR‑665 expression was decreased in ovarian cancer tissues. Increased expression of miR‑665 suppresse...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
The approval of PARP inhibitors has caused a paradigm shift in ovarian cancer management and a challenge for clinicians, who must decide how best to use these agents in individualized treatment.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Results of a phase I clinical trial highlight how the addition of a drug to an existing treatment option appears safe and may improve outcomes in certain patients with malignant pleural mesothelioma (MPM). The primary goal of the trial was to determine the maximum tolerated dose of gemcitabine added to cisplatin when these drugs are delivered together as heated intraoperative chemotherapy (HIOC) during surgery. Researchers have studied cisplatin alone for HIOC. The addition of gemcitabine — a chemotherapy drug often used to treat pancreatic, ovarian and breast cancers — is new. The Journal of Thoracic Oncology...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
(Rockefeller University) A new study helps explain why certain cancers don't respond to treatment, and offers hope for overcoming this deadly resistance.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Publication date: Available online 17 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph J. Caumanns, G. Bea A. Wisman, Katrien Berns, Ate G.J. van der Zee, Steven de JongAbstractSWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are predominantly mutated across cancers. The highest mutation incidence is found in ARID1A, primarily consisti...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
SummaryWe performed an in-vitro study testing the chemosensitivity of peritoneal cancer cell lines (SW620, HCT116, MKN45, 23,132/87, OAW42) to various cytostatic drug regimens. A duplex drug, characterized by reversible linking of the antimetabolites 2 ′-deoxy-5-fluorouridine (5-FdU) and 3’-C-ethynylcytidine (ECyd), was compared to oxaliplatin or to cisplatin plus doxorubicin. The experiments were designed to reflect the conditions of intraperitoneal chemotherapy. CASY® (Cell Analysis System) technology was used to compare the impact of incub ation temperature/duration and drug concentration on the viabilit...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
When it comes to anti-cancer drugs, it’s not only their effectiveness at killing the intended target that we want to know, but also their ability to reach and penetrate the cancer cells. Knowing whether the drug actually enters cancer cells can...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Materials Oncology Source Type: blogs
No increased risk of corpus uteri, invasive breast cancer for women undergoing assisted reproduction
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Journal, Source Type: news
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