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Love Your Hair Color? You Have 100 Genes to Thank

The researchers who pinpointed the origins of hair hue said their findings could improve understanding of health conditions linked to pigmentation, including skin, testicular, prostate and ovarian cancers.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: July 2018 Source:Redox Biology, Volume 17 Author(s): Dong Hou, Zhaojian Liu, Xiuhua Xu, Qiao Liu, Xiyu Zhang, Beihua Kong, Jian-Jun Wei, Yaoqin Gong, Changshun Shao PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attributed to impaired DNA repair. We here report that oxidative stress is also increased by PARP inhibition and mediates the antitum...
Source: Redox Biology - Category: Biology Source Type: research
Inflammatory Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Stem Cell-Like Characteristics of Cancer Cells in an IL-1β-Dependent Manner. Biomed Res Int. 2018;2018:7096707 Authors: Luo X, Huang S, He N, Liu C, Chen Y, Liu Y, Mi X, Li N, Sun P, Li Z, Xiang R, Su W Abstract To ensure the safety of clinical applications of MSCs, thorough understanding of their impacts on tumor initiation and progression is essential. Here, to further explore the complex dialog between MSCs and tumor cells, umbilical cord-derived mesenchymal stem cells (UC-MSCs) were employed to be cocultured with either ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS Polymorphisms of the RASSF1A gene, most significantly the CT genotype of rs1989839, might play a role in the development and prognosis of ovarian cancer in women in Southern China. To our knowledge, this is the first study to demonstrate an association between polymorphisms in the RASSF1A gene in ovarian cancer. PMID: 29670073 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating). The radiation dose to the ov...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: 21 April 2018 Source:New Scientist, Volume 238, Issue 3174
Source: New Scientist - Category: Science Source Type: research
As childhood cancer diagnoses increase and treatments improve survivorship, fertility preservation has emerged as an integral component of the comprehensive cancer treatment plan. The 5-year overall survival rate for childhood cancer has increased from 58% in patients diagnosed between 1975 and 1977 to 83% in those diagnosed between 2002 and 2008 (1). The American Society of Clinical Oncology recognizes fertility preservation as a key survivorship issue and utilizes fertility treatment as a quality care measure.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
CONCLUSIONS: D-FP21-PEG-PEI/plasmid DNA is a safe and efficient gene delivery vehicle for ovarian cancer targeted therapy. PMID: 29667478 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Sabatucci I, Maltese G, Lepori S, Tripodi E, Bogani G, Lorusso D Abstract INTRODUCTION: Approximately 50% of high-grade serous ovarian cancers present a deficiency in the pathways involved in homologous recombination (HR). PARP inhibitors prevent single-strand DNA damage repair and determine a progression of the defect towards double-strand breaks, which results in a process known as 'synthetic lethality'. Areas covered: In this review, the authors discuss the efficacy and toxicity of rucaparib either as a single agent or as a maintenance treatment for ovarian cancer. This includes the NGS Foundation Medic...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
The new paradigm of mutations in chromatin modifying genes as driver events in the development of cancers has proved challenging to resolve the complex influences over disease phenotypes. In particular, impaired activities of members of the SWI/SNF chromatin remodeling complex have appeared in an increasing variety of tumors. Mutations in SNF5, a member of this ubiquitously expressed complex, arise in almost all cases of malignant rhabdoid tumor in the absence of additional genetic alterations. Therefore, we studied how activation of additional oncogenic pathways might shift the phenotype of disease driven by SNF5 loss.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Short Communication Source Type: research
This article reviews the emerging roles of functional imaging in the assessment of peritoneal carcinomatosis in ovarian cancer, focusing on the use of diffusion-weighted magnetic resonance imaging (DW-MRI) and 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography combined with computed tomography (PET-CT), their advantages and shortcomings as well as the added-value over conventional imaging.
Source: Clinical Radiology - Category: Radiology Authors: Tags: Pictorial Review Source Type: research
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