Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms.

Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms.
Curr Opin Microbiol. 2018 Apr 12;45:109-116
Authors: Palazzotto E, Weber T
Abstract
Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have importantly contributed to the renaissance of new antibiotic discovery increasing our understanding of complex mechanisms controlling the expression of biosynthetic gene clusters (BGCs) encoding secondary metabolites. In this context this review highlights recent progress in the use and integration of 'omics' approaches with focuses on genomics, transcriptomics, proteomics metabolomics meta-omics and combined omics as powerful strategy to discover new antibiotics.
PMID: 29656009 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - April 12, 2018 Category: Microbiology Authors: Palazzotto E, Weber T Tags: Curr Opin Microbiol Source Type: research