The Art of Medicine: Taking a Military History
This article was prepared by the authors above in his/her personal capacity. The opinions expressed in this article are the author’s own and do not reflect the view of the Department of Veterans Affairs, VA Connecticut Healthcare System or the United States government. Title: The Forgotten Question: Taking a Military History Authors: Meredith Bertrand, NP1 Eugenia Betz, MD1,2 Alice Grant, NP1 Leila Haghighat, MD1,2 Janet Ku, NP1 Sumit R. Kumar, MD1,2 Mona Lalehzari, MD1,2 Benjamin Y. Lu, MD1,2 J. Nicholas Pumilia, MD1,2 Jonathan Stock, MD1,2 Anna Reisman, MD1,2,3 1. VA Centers of Excellence in Primary Care Education, West Haven Veterans Affairs Hospital, West Haven, CT 2. Department of Internal Medicine, Yale School of Medicine, New Haven, CT 3. Program for Humanities in Medicine, Yale School of Medicine, New Haven, CT.
ConclusionIn conclusion, hypothalamic Pomc as well as Mc4r, both of which are reduced in type 1 diabetic mice, are required for normal counterregulatory responses to hypoglycemia. Therefore, enhancing MC4R function may improve hypoglycemia counterregulation in diabetes.Graphical abstract
Antonella Stoppacciaro, Serena Di Vito, Patrizia Filetici
In conclusion, C. chrysanthus flowers can be suggested as a source of bioactive components with potential use against chronic disorders caused by oxidative stress. Future in-depth studies are recommended to determine the biological effects of isolated compounds from C. chrysanthus to identify the main compounds modulating the observed activities.
In this study, a PEG-modified liposome was developed for efficiently encapsulating CBZ, thus enhancing its specific tumor inhibition effect and reducing the systemic toxicity. It was found that the loading efficiency of CBZ into the liposome could be improved with the increase of lipophilic materials, as it could be over 80% under the weight ratio of 20:1 (total lipid: CBZ). The diameter of CBZ loaded liposome (CBZ@Lipo) was ∼100 nm. And the liposome suspending in aqueous medium was stable at 4 °C for at least one month, according to the change of its size distribution. The killing ability of CBZ@Lipo to cancer cel...
This study was aimed at investigating the inhibitory potential of A. senegalensis leaf extracts and fractions on the activities of some enzymes (α-amylase and α-glucosidase) linked to diabetes. Plant samples were extracted with n-hexane (HEX), ethyl cetate (EtOAc) and ethanol (EtOH) and the extracts were subjected to in vitro antidiabetic studies. The most active extract was further fractionated using column chromatography and the fractions obtained were screened for the inhibitory activities whilst the possible bioactive compounds were determined by Gas Chromatography Mass Spectroscopy (GC-MS). From the result...
Publication date: Available online 19 November 2018Source: Journal of Herbal MedicineAuthor(s): Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei LiuAbstractBlack salve, used as an alternative skin cancer therapy, contains both herbal and chemical constituents, including extracts of the rhizomes of Sanguinaria canadensis and zinc chloride. Black salves may be ordered online and have been associated with cases of extensive tissue necrosis and treatment failures that have resulted in patient fatalities. Despite these adverse outcomes and continued use by patients, black salve products have not be...
Conclusion: In the most compromised lung cancer patients, VATS sublobar resection might be the best option.
Conclusions: Our study suggests that the evaluation of lymph nodes via groin dissections in groin sarcomas in the Asian population should be based primarily on clinical and radiologic evidence. Regional lymph node dissection seems to confer OS benefit in patients with these high-risk tumors and can improve local control of disease.
Conclusions: Cure with a microscopically positive margin was suboptimal (71%) despite patients having classic-histology papillary and follicular carcinoma, favorable stage, and moderate-dose I-131 therapy.
Conclusions: These results affirm that patients with OMCC have extended OS periods and that stereotactic body radiotherapy offers strong local control in these settings. We show that even in the oligometastatic setting those with right-sided primary tumors have worse outcomes relative to those with left-sided or rectal primary tumors. This suggests more aggressive treatment may be needed for those with oligometastatic right-sided colorectal cancer.
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