Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins.

Conclusions: Inhaled cyclodextrins have potential for the treatment of ARDS. They could be delivered in a portable device carried in combat and used following exposure to toxic gases and fumes or shock secondary to hemorrhage and burns. PMID: 29635617 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research

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A new study aims to elucidate the link between PCSK9 inhibitors and glucose metabolism. Might they increase the risk of diabetes, as statins have been shown to do?European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Knowing the odds of side effects and making sure to get periodic checkups that would pick up an adverse reaction, I chose to focus on the drugs ’ potential benefits.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cholesterol Statins (Cholesterol-Lowering Drugs) Heart Drugs (Pharmaceuticals) Diet and Nutrition Alzheimer's Disease Source Type: news
ConclusionThe extracted rules after experimentation are understandable and informative to the technical and nontechnical community to predict HBP.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Authors: Yu TY, Jin SM, Jee JH, Bae JC, Lee MK, Kim JH Abstract BACKGROUND: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects. METHODS: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with develop...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Publication date: Available online 16 March 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): S. Harrison, C. Couillard, J. Robitaille, M.-C. Vohl, M. Bélanger, S. Desroches, V. Provencher, R. Rabasa-Lhoret, L. Bouchard, M.-F. Langlois, J. Houle, S. Lemieux, B. LamarcheAbstractBackground and aimsThe “Life’s Simple 7” (LS7) metrics were developed by the American Heart Association (AHA) to assess and promote cardiovascular health in the American population. The purpose of this study was to assess the overall CV health of French-speaking adults from the Province of Quebec using t...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: Available online 16 March 2019Source: Microbial PathogenesisAuthor(s): Liu Caixia, Xiang Yang, Tan Yurong, Qin XiaoqunAbstractThe epithelial cells of bronchi (BECs) act as a protective wall against potential pathogens and foreign particles that controls many aspects of respiratory immune response. The BECs act as not only a physical protecting wall of the airways but also as a significant part of both the innate and adaptive immune responses. Many kind of epithelium-associated communicating pathways which are triggered by genetic and environmental causating agents get involved in development of respirator...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Authors: Fang Y, Wu D, Birukov KG Abstract Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell elements regulated by dynamic interactions between cytoskeletal elements and cell adhesion complexes. ECs also participate in many other vital processes including innate immune reactions, vascular repair, secretion, and metabolism of bioactive molecules. Moreover, vascular ECs represent a unique cell type exposed to continuous, time-dependent mechanical forces: different patterns of shear stress imposed by blood flow in macrovasculature and by rolling blood cells in the microvasculatu...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Cook MJ, Sorial AK, Lunt M, Board TN, O'Neill TW Abstract OBJECTIVE: To determine whether the timing and also duration of statin exposure following total hip/knee arthroplasty (THA/TKA) influences the risk of revision arthroplasty. METHODS: Subjects from the Clinical Practice Research Datalink, a large population-based clinical database, who had THA/TKA from 1988-2016 were included. Propensity score adjusted Cox regression models were used to determine the association between statin exposure and the risk of revision THA/TKA, i) at any time and ii) if first exposed 0-1, 1-5, or>5 years following THA/...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Publication date: May 2019Source: Journal of Functional Foods, Volume 56Author(s): María José Villanueva-Suárez, Inmaculada Mateos-Aparicio, María Luisa Pérez-Cózar, Wallace Yokoyama, Araceli Redondo-CuencaAbstractDietary fibre, including inulin-type fructans, from artichoke by-product were analyzed to understand the potential hypolipidemic effects over Syrian Hamsters fed a high fat diet. A decrease (p 
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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