Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins.

Conclusions: Inhaled cyclodextrins have potential for the treatment of ARDS. They could be delivered in a portable device carried in combat and used following exposure to toxic gases and fumes or shock secondary to hemorrhage and burns. PMID: 29635617 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research

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Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population.
Source: Revista de Psiquiatria Clinica - Category: Psychiatry Source Type: research
Hsp90 is a molecular chaperone which is engaged in the repair of diverse oncogenic proteins. Additionally, it is overexpressed in cancer cells along with co-chaperones, whereas normal cell Hsp90 (less than 2 % of cellular proteins) resides in an uncomplexed state. Hence, this chaperone is an encouraging target for the discovery of novel chemical entities against cancer. Proteins execute their functions by interacting with various macromolecules. The conformational flexibility of polypeptides helps them to adopt a shape corresponding to their partner molecules. Hsp90 is a highly flexible polypeptide which can accommodate a ...
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
Burns are injuries produced by application of dry heat such as flame, radiant heat or some heated solid substance like metal or glass to the body. Local injury to the body by heat may result from dry heat, application of hot bodies, licking by flames resul...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
In this study, oil-in-water emulsions containing a surfactant (triton X-100) and ferrocene (0-500 ppm) were prepared and their stabilities and capabilities to...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Current Building Standard Law of Japan estimates fire toxicity of building material in case of fire by gas toxicity test using mice. Because it is an animal test, some problems are identified such as the impossibility of quantitative analysis, and from eth...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Thermal burns are major cause of death and disability affecting to the developing countries like India. High mortality has become a medical problem in rural India. The females are the usual sufferers. The mortality is almost 100% at the extremes of the age...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 16 July 2018Source: Arthroscopy TechniquesAuthor(s): Anne Jonkergouw, Jelle P. van der List, Gregory S. DiFeliceAbstractKnee dislocations often result in a severe multiligament injured knee (MLIK) with complex instability. Multiligament reconstruction can successfully restore knee stability and is commonly recommended, although surgical morbidity is induced by graft harvesting and tunnel drilling, and convergence of multiple tunnels can complicate the surgery. Therefore, as an alternative, primary repair of knee ligaments is currently reconsidered. The main advantages of primary repair co...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
The promising new treatment option stems from Yale Cancer Center findings that the cancers are driven by a breakdown in how cells repair their DNA.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
Condition:   Acute Pain Interventions:   Drug: liposomal bupivacaine;   Drug: Bupivacaine Sponsor:   University of Minnesota - Clinical and Translational Science Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Capsaicin;   Ultaviolet B Light Burn;   Neuropathic Pain;   Lidocaine Interventions:   Drug: Capsaicin Topical;   Radiation: Ultraviolet-B (UVB) irradiation;   Other: Histamine 1%;   Drug: Lidocaine Sponsor:   Aalborg University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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