Renal cell carcinoma for the nephrologist

Renal cell carcinoma (RCC), a malignancy whose incidence is increasing, is frequently encountered in general nephrology practice when acute and chronic kidney disease occurs in the course of disease. Importantly, when kidney disease develops in the setting of RCC, mortality is significantly increased with patients often dying of a non-cancer-related complication of kidney disease. As such, practicing nephrologists need to have a working knowledge of this cancer ’s biology, treatment, and complications.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research

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Publication date: Available online 24 September 2018Source: European UrologyAuthor(s): Boris Gershman, R. Houston Thompson, Stephen A. Boorjian, Christine M. Lohse, Brian A. Costello, John C. Cheville, Bradley C. LeibovichAbstractBackgroundNephron-sparing surgery is the preferred surgical management of cT1 renal masses, but observational and randomized data conflict regarding a survival benefit.ObjectiveTo examine the associations of radical nephrectomy (RN) versus partial nephrectomy (PN) with oncologic and nononcologic outcomes.Design, setting, and participantsA total of 2459 adults were treated with RN or PN between 199...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Smoking, obesity, hypertension and chronic kidney disease are risk factors for kidney cancer.09/28/2018
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
Authors: Zhang X, Chen L Abstract Renal cell carcinoma (RCC) and chronic kidney disease (CKD) are associated with hypoxia, but the effects of hypoxia on the process of angiogenesis in the two diseases are dramatically different. Some of matrix metalloproteinases (MMPs), such as MMP2 and MMP9, may have a role because they represent the most prominent family of proteinases associated with angiogenesis. In the present study, the differential response of human renal cell cancer cells (786-0), human renal tubular epithelial cells (HK-2) and human microvascular endothelial cells (HMEC-1) to hypoxia with regards to the ex...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Charytoniuk T, Małyszko M, Bączek J, Fiedorczyk P, Siedlaczek K, Małyszko J Abstract Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in chronic kidney disease risk factors after nephrectom...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionsIn patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival.Patient summaryThe relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Authors: Yuki H, Kamai T, Murakami S, Higashi S, Narimatsu T, Kambara T, Betsunoh H, Abe H, Arai K, Shirataki H, Yoshida KI Abstract Chronic kidney disease (CKD) is a worldwide health problem, and prevention of CKD is important for preservation of renal function after kidney surgery. There is evidence that transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has a vital antioxidant and detoxifying role in protecting the kidneys against various diseases. Impaired activation of Nrf2 is associated with oxidative stress related to CKD, and Nrf2 is also a key player in the development of cancer. Howev...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Partial nephrectomy (PN) for clinically localized renal cell carcinoma (CLRCC) allows for comparable oncologic benefit to radical nephrectomy with improved preservation of renal function in pT1-T2 masses. The decreased impact on GFR in patients within normal or near normal renal function is less important than the change observed in those patients with chronic kidney disease (CKD). We aimed to investigate the rates and risk factors for CKD upstaging after PN in patients with normal and at-risk kidneys, and to understand how surgically modifiable factors influence that relationship.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Localized: Surgical Therapy VI Source Type: research
Though radical cytoreductive nephrectomy has been shown to improve overall survival in patients with metastatic renal cell carcinoma, the impact this treatment has on renal function has not been adequately assessed. Radical nephrectomy in patients with localized cancer has been associated with risk of chronic kidney disease development. Using patients enrolled in ADAPT trial that received cytoreductive nephrectomy in the metastatic setting, we intend to study the effect of this procedure on overall renal function in patients without kidney disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Localized: Surgical Therapy IV Source Type: research
In this study, we examined the associations of RN versus PN with oncologic and non-oncologic outcomes using a large institutional cohort.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Localized: Surgical Therapy V Source Type: research
Conclusion: Our hypothesis that a chronic uranium exposure is associated with an increased risk of cancer mortality or of kidney failure is refuted by clinical data. The decreased risk may result from better medical surveillance of uranium workers.Nephron Extra 2016;6:1-11
Source: Nephron Extra - Category: Urology & Nephrology Source Type: research
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