Methods for identification of spike patterns in massively parallel spike trains.
Methods for identification of spike patterns in massively parallel spike trains. Biol Cybern. 2018 Apr 12;: Authors: Quaglio P, Rostami V, Torre E, Grün S Abstract Temporally, precise correlations between simultaneously recorded neurons have been interpreted as signatures of cell assemblies, i.e., groups of neurons that form processing units. Evidence for this hypothesis was found on the level of pairwise correlations in simultaneous recordings of few neurons. Increasing the number of simultaneously recorded neurons increases the chances to detect cell assembly activity due to the larger sample size. Recent technological advances have enabled the recording of 100 or more neurons in parallel. However, these massively parallel spike train data require novel statistical tools to be analyzed for correlations, because they raise considerable combinatorial and multiple testing issues. Recently, various of such methods have started to develop. First approaches were based on population or pairwise measures of synchronization, and later led to methods for the detection of various types of higher-order synchronization and of spatio-temporal patterns. The latest techniques combine data mining with analysis of statistical significance. Here, we give a comparative overview of these methods, of their assumptions and of the types of correlations they can detect. PMID: 29651582 [PubMed - as supplied by publisher]
Authors: Braga ACM, Pinto A, Pinto S, de Carvalho M Abstract Introduction: The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention. Methods: We included 48 ALS patients randomized in 2 groups: G1 (n = 24), exercise intensity leveled by CPET; G2 (n = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (T1) and 6 months later (T2). We registered oxygen uptake, car...
Authors: Alanazy MH, Barakeh RB, Asiri A, Edrees MF, Abuzinadah AR, Aljafen BN, Muayqil T Abstract Only a small fraction of patients with acute ischemic stroke receive intravenous thrombolysis (IVT). We sought to assess barriers and practice patterns in using IVT for acute ischemic stroke among neurologists in Saudi Arabia. An electronic survey was sent to all neurologists registered with the Saudi Commission for Health Specialties. A total of 148 (77.5%) neurologists responded. The most common reported barriers for IVT administration were delayed presentation to hospitals (82.4%) and unclear time of symptom onset ...
Helena Wang talks to Peng Gong aboutThe Lancet-Tsinghua Healthy Cities Commission, what needs to be done to evaluate the progress and promote healthy cities in China. This podcast is in Chinese.
Authors: PMID: 29667450 [PubMed - as supplied by publisher]