Investigation and treatment of prefibrotic/early primary myelofibrosis. A case study.

[Investigation and treatment of prefibrotic/early primary myelofibrosis. A case study]. Orv Hetil. 2018 Apr;159(15):603-609 Authors: Magyari F, Bedekovics J, Décsy J, Ilonczai P, Illés Á, Simon Z Abstract Moderate thrombocytosis can accompany several diseases (bleeding, inflammation, iron deficiency, or autoimmune diseases), but hematologic examination is strongly recommended in a patient with persistent platelet count above 450 G/L unless reactive origin can be confirmed. The 47-year-old woman's medical history included hypertonia, asthma bronchiale, and endometriosis. In March 2015, she underwent laboratory examination due to weight loss and lack of appetite. Her results showed elevated thrombocyte count (617 G/L), but no iron deficiency. She presented in our clinic on 07. 04. 2015 with acute pain below her left hypochondrial region, but simple imaging examinations showed no difference to explain it. Abdominal CT revealed a 4.5 cm thrombus which protruded into the left renal artery, blocking it. We started APTI- (activated partial thromboplastin time) monitored continuous intravenous treatment with unfractionated heparin. The JAK2V617F mutation analysis came back positive. Subsequent bone marrow examination revealed prefibrotic/early stage myelofibrosis, prompting treatment with hydroxyurea. The applied treatments led to the disappearance of the patient's symptoms accompanied by the gradual normalisation of the thrombocyte count. M...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research

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This study has been carried out in order to investigate the frequency and causes of consuming supplements and understanding the side effects related to their consumption among bodybuilders in Kermanshah City. Methods: The samples of this cross-sectional study include teenagers and young adults who are the members of fitness gyms around Kermanshah City. 244 individuals were selected as samples using simple random sampling. In order to gather the required data, a four-sectioned questionnaire designed by the research team was used. The data analysis was done using chi-square, independent ttest, and Pearson's and Spearman...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
This study confirmed the weight control effect of chitosan in the context of high-fat diet consumption. Interestingly, chitosan increased the serum leptin level in the high-fat diet groups and increased the oral glucose tolerance in the low-fat diet groups. Chitosan reduced the chronic inflammation caused by high-fat diet consumption. Moreover, the intestinal microbiome was influenced by the chitosan intervention as the feeding time increased. Chitosan supplementation increased the anti-obesity-related species, such as Coprobacillus cateniformis and Clostridium leptum, and significantly decreased Clostridium lactatiferment...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
CONCLUSIONS: The practice of self-medication with analgesics is frequent among patients with chronic pain, which may be due to the underprescription of more potent analgesics, such as opioids. It can also be said that, given the data presented, there is no crisis of recreational opioid use in the studied population. PMID: 31703816 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
ConclusionFurther studies are needed to evaluate the molecular mechanisms involved in the behaviour of MLT in EAE, and to quantify other cytokines in different biological media in order for MLT to be considered an anti-inflammatory agent capable of regulating MS.ResumenIntroducciónLa esclerosis múltiple (EM) es una enfermedad crónica desmielinizante autoinmune del sistema nervioso central (SNC) que produce neuroinflamación, un modelo es la encefalitis autoinmune experimental (EAE). La EM ha sido tratada con interferón beta (IFN-beta) y acetato de glatiramero (AG). Se ha descrito que la me...
Source: Neurologia - Category: Neurology Source Type: research
Abstract Sex hormones are best known for their influences on reproduction, but they also have profound influences on the immune response. Examples of sex-specific differences include: (i) the relatively poor control of influenza virus infections in males compared to females, (ii) allergic asthma, an IgE-associated hypersensitivity reaction that is exacerbated in adolescent females compared to males, and (iii) systemic lupus erythematosus, a life-threatening autoimmune disease with a 9:1 female:male bias. Here we consider how estrogen and estrogen receptor α (ERα) may influence the immune response by mo...
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Tags: Cell Immunol Source Type: research
AbstractIntroductionOral semaglutide is the first orally administered glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes, and has been evaluated in the PIONEER clinical trial program. These trials assessed the proportions of patients achieving single and composite endpoints, encompassing glycemic control [defined in terms of glycated hemoglobin (HbA1c)], weight loss, and hypoglycemia. The present study assessed the cost of control with oral semaglutide versus empagliflozin, sitagliptin, and liraglutide in the US.MethodsFour endpoints were evaluated: (1) HbA1c ≤ 6.5%; (2) HbA1c
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
ABSTRACT The replacement of natural teeth that have extreme external apical root resorption, induced by orthodontic treatment, with osseointegrated implants is not justifiable biologically or clinically. These teeth should be preserved and keep their normal functions, as there is no greater mobility, pain or color change. They may undergo usual procedures, such as bleaching, restorations with veneers and other esthetic procedures that may be necessary along life. The pulp of these teeth is normal. If mobility of a tooth with extreme resorption is identified, the cause of mobility should be investigated, as it is not associ...
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You're reading Can Mindfulness Meditation Really Reduce Pain and Suffering?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. There are many scientifically-validated claims about meditation's myriad benefits, but can it actually reduce chronic pain? One study demonstrated a significant decrease in chronic pain-related suffering from 10 weeks of mindfulness meditation. Another study found that meditation improves pain tolerance by 57%. How is this possible? To make sense of these results, it helps to know the diff...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement meditation pain Source Type: blogs
Conclusion: Triclosan-coated suture shows lower infection rate in saphenectomy of patients undergoing CABG, although the differences were not statistically significant. Pain and wound hyperthermia were less frequent in patients with triclosan-coated sutures compared with conventional sutures.
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
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