Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) Syndrome and Carcinoid Tumors With/Without NECH: A Clinicopathologic, Radiologic, and Immunomolecular Comparison Study

In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH. None of the cases displayed molecular alterations or anaplastic lymphoma kinase expression. Compared with individuals with carcinoids with/without NECH, patients with DIPNECH were more likely to be female individuals (P
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research

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1331Objectives: To investigate the role of 18F-FDG PET/CT in the management of bilateral adrenal gland lesions. Methods: Retrospectively collect patients with pathology-proved bilateral adrenal lesions (>2cm in diameter), who also underwent pre-therapy 18F-FDG PET/CT scan between Jan 2013 and Nov 2017. SUVmax of the adrenal lesions and the remote lesions on PET/CT were recorded. P
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
1373Objectives: To collect preliminary data on 82-Rb (Rb) uptake in malignant tumors on PET/CT. Methods: The data warehouse of our institution was searched for all patients with a histologically proven, untreated malignancy at the time of cardiac Rb PET/CT since its introduction in October 2008 until August 31, 2015 . Two radiologists reviewed Rb PET/CT images and compared Rb uptake of the dominant lesion (LIS) in each patient to the Rb uptake in the liver (LIV), mediastinum blood pool (MBP), lung (LUN) and subcutaneous fat uptake (SCF). Lesion uptake was scored as 4 (LIS> LIV), 3 (LIV> LIS> MBP), 2 (MBP> LIS&g...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research
CONCLUSION: Although all of the appendectomy samples were normal macroscopically, data from this study suggest that all specimens should be sent for routine investigation. KEY WORDS: Appendicitis, Appendectomy, Carcinoid, Mucocele, Endometriosis. PMID: 29339597 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusion: Jordan is a low-risk area for gastric cancer, but carcinoma occurs at a young age and is associated with gastritis, Helicobacter pylori infection, and intestinal metaplasia in a large proportion of cases. Better strategic health planning and early detection is needed, especially in young patients suffering from gastritis. PMID: 28889157 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Small bowel tumors (SBTs) are uncommon. They represent between 2% -5% of all gastrointestinal tumors (GIT). They may be primary (pSBTs) such as adenocarcinoma, sarcoma, carcinoid or neuroendocrine tumors (NET), gastrointestinal stromal tumors (GIST) and lymphoma or metastatic (mSBTs). Data about SBTs in Chile is limited.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Sunday – ASGE poster Source Type: research
Abstract Although gastric tumors have overlapping radiologic appearances, some unusual tumors may present specific imaging features. Using multidetector computed tomography (MDCT), with water as a negative oral contrast agent and intravenous contrast medium, can provide critical information for the diagnosis of gastric diseases. In addition, MDCT can evaluate the involvement of the gastric wall and extragastric extent of the disease, as compared with gastroenteroscopy and double-contrast upper gastrointestinal study. Regarding lesion location and size, enhancing and growth patterns, presence of calcification or fa...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Authors: Juanmartiñena JF, Montes M, Fernández-Urién I Abstract An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous d...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
AbstractFocal small bowel lesions present a diagnostic challenge for both the radiologist and gastroenterologist. Both the detection and characterization of small bowel masses have greatly improved with the advent of multidetector CT enterography (MD-CTE). As such, MD-CTE is increasingly utilized in the workup of occult gastrointestinal bleeding. In this article, we review the spectrum of focal small bowel masses with pathologic correlation. Adenocarcinoma, the most common primary small bowel malignancy, presents as a focal irregular mass occasionally with circumferential extension leading to obstruction. Small bowel carci...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Authors: Nakajima M, Uchiyama N, Shigemasa R, Matsumura T, Matsuoka R, Nomura A Abstract This is the first report in which crizotinib, an anaplastic lymphoma kinase (ALK) inhibitor, reduced an atypical carcinoid tumor with ALK rearrangement. A 70-year-old man developed a tumor in the left lung and multiple metastases to the lung and brain. The pathology of transbronchial biopsied specimens demonstrated an atypical carcinoid pattern. Combined with immunohistochemical findings, we diagnosed the tumor as atypical carcinoid. ALK gene rearrangement was observed by both immunohistochemical (IHC) and fluorescence in situ ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We read with some interest the report submitted by Ditah and colleagues1 in this issue of the Journal, which reviews a case of hemoptysis in a 19-year-old woman. The story sounded familiar, and even after skimming over the title, the answer seemed to be as well rehearsed as the latest production of Phantom of the Opera (now 30  years into its iconic run). Hemoptysis in a 19-year-old? Carcinoid, mucoepidermoid tumor, broncholith, lymphoma, foreign body, arteriovenous malformation, sequestration, trauma, pulmonary embolism, sarcoma, adenoma, trauma, and—reaching way out into left field—even Eisenmenger syndr...
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Editorial commentary Source Type: research
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