Intralymphatic Spread is a Rare Finding Associated With Poor Prognosis in Diffuse Large B-Cell Lymphoma With Extranodal Involvements
In conclusion, our study demonstrated extranodal intralymphatic spread in DLBCL. Inspiringly, this rare morphologic finding may serve as a new negative prognostic indicator in DLBCL with extranodal involvements.
Immunodeficiency, whether congenital or acquired, iatrogenic (e.g. allograft recipients) or infectious (e.g. human immunodeficiency virus (HIV)), is associated with an increased risk of malignancy. In the case of HIV infection, most cancers are associated with oncogenic virus infection. Although the overall risk of any cancer is increased 2 –3-fold in people living with HIV, there are three acquired immune deficiency syndrome (AIDS)-defining cancers whose relative risk is dramatically higher. These three AIDS-defining illnesses are Kaposi's sarcoma, high-grade B cell non-Hodgkin's lymphoma (including primary cerebral...
AbstractThe geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI
AbstractRecent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients. PFS was evaluated accordingly to Kaplan-Meier method. Higher NLR was associated to ad...
Asia-Pacific Journal of Clinical Oncology, EarlyView.
Conclusions: In our study, the results we presented showed apatinib might have a rapid, safe and high efficacy on relapsed or refractory non-Hodgkin lymphoma patients. Based on the data more clinic trials are expected to be taken to identification the efficacy of apatinib on lymphoma further. PMID: 29662638 [PubMed]
Sezary syndrome (SS) is an aggressive, leukemic variant of cutaneous T cell lymphoma. Clinical and histopathological findings, including T cell receptor gene clonality may not differentiate SS from inflammatory dermatoses. DNA methylation may provide useful biomarkers, which are needed for more reliable diagnosis, therapies, and to provide tools for research into disease mechanisms. Our group has previously reported a positive association in SS between high expression of TWIST1, PLS3 and GATA6 mRNAs with promoter DNA hypo-methylation, as determined by targeted pyrosequencing.
Cancer therapies commonly slow disease and most patients ultimately relapse. Here we show at the single-cell level that cutaneous lymphoma cells are programmed to occupy a rare transient, drug-resistant state. Our work defines a panel of drug-resistance markers allowing identification of this cellular subset in patients. Single-cell analyses reveal a small fraction of cells resisting commonly used drugs such as doxorubicin, vorinostat, and methotrexate. In cell fate analyses, we observed that drug treatment leads to selective survival of label-retaining cells leading to re-growth of xenograft tumors consistent with a relap...
Cutaneous T-Cell Lymphomas (CTCL) exhibit an aggressive form of genomic instability resulting in chromosomal aberrations that ultimately drive cancer development and progression. Despite their role in carcinogenesis, their molecular pathogenesis remains poorly understood. A recent study shows that cancer testis (CT) antigens are found to be ectopically expressed in CTCL and a variety of cancers, begging the question if meiomitosis, a process when daughter cells inherit the partial expression of meiotic machinery following mitosis, contributes to increased genomic instability.
DNA hydroxymethylation at the 5 position of cytosine (5-hmC) is a product of the ten-eleven translocation (TET) family of DNA hydroxylases. Accumulating pieces of evidence showed that loss of 5-hmC is critical for various biological and pathological processes. However, its expression and function in cutaneous T cell lymphoma remain largely unknown. Here, with a large cohort of patients, we report that loss of 5-hmC is an epigenetic hallmark of cutaneous T cell lymphoma, with diagnostic and prognostic implications.
Mycosis fungoides (MF) is a rare, generally indolent non-Hodgkin lymphoma of the skin. In a large, population based study of the SEER-18 database, we recently found that patients with mycosis fungoides are at increased risk of developing second malignancies. This case-control study examines factors associated with development of second malignancies in 172 MF patients treated at the University of Minnesota from 2005-2017. We identified 172 patients with MF, median age of 59 years (range, 8-89). As a control group, we identified 175 patients with seborrheic dermatitis (SD), median age of 61.4 years (range 14.4-88.3, p> 0.3).