ACUDIN – ACUpuncture and laser acupuncture for treatment of DIabetic peripheral Neuropathy: a randomized, placebo-controlled, partially double-blinded trial

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus with significant clinical sequelae that can affect a patient ’s quality of life. Metabolic and microvascular factors are...
Source: BMC Neurology - Category: Neurology Authors: Tags: Study protocol Source Type: research

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The prevalence of type 2 diabetes mellitus (T2DM), which results in many micro- and macrovascular complications with major morbidity, mortality, reduced quality of life and increased society costs, is rapidly increasing worldwide and is becoming a major global health issue [1 –3]. Diabetic foot ulcer (DFU), which is often associated with infection, peripheral neuropathy and peripheral arterial disease, is one of the most serious and problematic complications of diabetes and has been considered the most important predictor for lower-extremity amputations [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Publication date: June 2018Source: Fuß &Sprunggelenk, Volume 16, Issue 2Author(s): Andrea B. Rosskopf, Martin C. BerliZusammenfassungDer Charcot-Fuss ist assoziiert mit einer peripheren Neuropathie und tritt in der Regel bei Patienten mit langjährigem Diabetes mellitus auf. Das Krankheitsbild ist selten, kann zu ausgeprägten Fuss-Destruktionen führen und die Patienten im Alltag sehr beeinträchtigen. Die radiologische Bildgebung spielt eine zentrale Rolle während der gesamten orthopädischen Behandlung dieser Erkrankung. Insbesondere die Magnetresonanztomografie ist die Methode der Wah...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Shruti Jaiswal, Sanjay Mishra, S.S. Torgal, Sushant ShenguleAbstractAimsType-2 diabetes mellitus (DM) is associated with cognitive impairment. Increasing evidence establishes that neuro-inflammatory and oxidative stress condition plays a main role in the development of neurodegeneration. Epalrestat, an aldose reductase inhibitor is commonly prescribed for the treatment of diabetic peripheral neuropathy. Its beneficial effects for antioxidant, anti-inflammatory potential and being rhodanine structure containing compound suggests possible role for tr...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsPrevalence of DM in patients with TTS is lower than in the general population, suggesting that DM, may have a “protective” effect for the emergence of TTS.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: May–June 2018Source: The Journal of Foot and Ankle Surgery, Volume 57, Issue 3Author(s): David Rettedal, Alissa Parker, Adam Popchak, Patrick R. BurnsAbstractCharcot neuroarthropathy is a destructive process that occurs in patients with peripheral neuropathy, often due to poorly controlled diabetes mellitus. Surgical reconstruction can be necessary to provide a plantigrade foot that is wound free. A risk of major amputation exists after a Charcot event and after attempted reconstruction. We retrospectively reviewed the data from 34 patients (36 reconstructions) who had undergone reconstructive surge...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
ConclusionEmodin protected PC-12 cells against high glucose-induced apoptosis and autophagy. The neuroprotective activities might be realized by up-regulation of miR-9, and modulation of PI3K/AKT and NF-κB signaling pathways.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 6 March 2018Source: Canadian Journal of DiabetesAuthor(s): Patricia Hewston, Nandini DeshpandeAbstractType 2 diabetes mellitus is highly prevalent in older adults (≥65 years of age) and increases fall risk. Fear of falling and low balance confidence are reported in both fallers and nonfallers and can potentially be more debilitating than a fall itself. Therefore, the objective of this scoping review was to examine and map the current research evidence of balance confidence and fear of falling in older adults with type 2 diabetes. A search of CINAHL, EMBASE and PubMed was conducted. The...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Shruti Jaiswal, Sanjay Mishra, S.S. Torgal, Sushant ShenguleAbstractAimsType-2 diabetes mellitus (DM) is associated with cognitive impairment. Increasing evidence establishes that neuro-inflammatory and oxidative stress condition plays a main role in the development of neurodegeneration. Epalrestat, an aldose reductase inhibitor is commonly prescribed for the treatment of diabetic peripheral neuropathy. Its beneficial effects for antioxidant, anti-inflammatory potential and being rhodanine structure containing compound suggests possible role for tr...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsPrevalence of DM in patients with TTS is lower than in the general population, suggesting that DM, may have a “protective” effect for the emergence of TTS.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: May–June 2018Source: The Journal of Foot and Ankle Surgery, Volume 57, Issue 3Author(s): David Rettedal, Alissa Parker, Adam Popchak, Patrick R. BurnsAbstractCharcot neuroarthropathy is a destructive process that occurs in patients with peripheral neuropathy, often due to poorly controlled diabetes mellitus. Surgical reconstruction can be necessary to provide a plantigrade foot that is wound free. A risk of major amputation exists after a Charcot event and after attempted reconstruction. We retrospectively reviewed the data from 34 patients (36 reconstructions) who had undergone reconstructive surge...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
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