Sex steroid hormones as neuroprotective elements in ischemia models

We describe updated data from receptor and signaling events triggered by both hormones, with an emphasis on the mechanisms that have been reported as ‘rapid’ or ‘cytoplasmic actions’. Data showing the therapeutic effects of the hormones, used alone or in combination, are also summarized, with a focus on rodent models of middle cerebral artery occlusion (MCAO). Finally, we draw attention to evidence that neuroprotection by both hormones might be due to a combination of ‘cytoplasmic’ and ‘nuclear’ signaling.

Source: Journal of Endocrinology - April 13, 2018 Category: Endocrinology Authors: Cespedes Rubio, A. E., Perez-Alvarez, M. J., Lapuente Chala, C., Wandosell, F. Tags: Review Source Type: research