Lack of sleep may be linked to risk factor for Alzheimer ’s disease

Preliminary NIH study shows increased levels of beta-amyloid  Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer ’s disease, according to a small, new study by researchers at the National Institutes of Health. In Alzheimer’s disease, beta-amyloid proteins clump together to form amyloid plaques, a hallmark of the disease. 
Source: NIAAA News - Category: Addiction Authors: Source Type: news

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There hasn’t been much good news about Alzheimer’s lately, between the March announcement by Biogen and Esai that a promising trial of a potential drug treatment failed, and the July decision by Novartis and Amgen to stop their study of another class of therapies for the neurodegenerative disease. But in a pair of studies presented at the annual Alzheimer’s Association International Conference on July 14, researchers reported encouraging results from studies of non-drug approaches. In one, scientists led by Dr. Klodian Dhana at Rush University Medical Center in Chicago followed nearly 2,500 people for alm...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain embargoed study Source Type: news
Alzheimer ’s disease (AD) is a globally common neurodegenerative disease, which is accompanied by alterations to various lifestyle patterns, such as sleep disturbance. The pineal gland is the primary endocrine ...
Source: Molecular Neurodegeneration - Category: Neurology Authors: Tags: Review Source Type: research
AbstractConcurrent mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are common in U.S. military service members and veterans. Tau and amyloid ‐beta‐42 (Aβ42) are proteins that have been linked to cognitive impairment, neurological hallmarks of Alzheimer's disease, and may also relate to recovery from mTBI. However, the role of these proteins in the maintenance or resolution of chronic symptoms has not yet been determined. Participant s in the current study were 102 service members and veterans who had sustained an mTBI (n = 84) or injured controls (IC) without TBI (n = 18). They were cat...
Source: Journal of Traumatic Stress - Category: Psychiatry & Psychology Authors: Tags: RESEARCH ARTICLE Source Type: research
AbstractPurpose of ReviewDeveloping pharmacological treatments to manage neuropsychiatric symptoms of Alzheimer ’s disease is of high importance due to its significant association with poorer outcomes, caregiver burden, and severity of disease. Due to limited effective and safe treatment options, we reviewed emerging research in novel pharmacological agents for the management of neuropsychiatric symptoms in Alzheimer’s disease.Recent FindingsWithin the past 5  years, 29 novel pharmacological agents to treat the neuropsychiatric symptoms of Alzheimer’s disease have been investigated or are currently i...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research
In this study, animals had free individual access to wheels to practice voluntary exercise. The Barnes Maze (BM) task was conducted with young and aged O. degus animals after combining voluntary exercise and either normal sleep or SD. Plasma cortisol levels were measured after each condition. SD impaired hippocampus-dependent memory in both young and old animals, while cortisol levels did not significantly differ between non-SD and SD animals. However, voluntary exercise for 45 days improved the cognitive impairment caused by SD compared with the control condition. Moreover, voluntary exercise decreased plasma cortisol lev...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
(Northwestern University) Gentle sound stimulation played during deep sleep enhanced deep sleep for people with mild cognitive impairment, who are at risk for Alzheimer's disease, a new study found. Those whose brains responded the most robustly to the sound stimulation showed an improved memory response the following day. These results suggest improving sleep is a promising novel approach to stave off dementia. The technology can be adapted for home use.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
There are a number of things that can increase the risk of dementia: age, of course, as well as certain genetic profiles and behaviors such as smoking and drinking. Some of the same things that contribute to heart disease, such as high cholesterol levels and the build up of plaques in the blood vessels, can also boost the chances of developing dementia. And in a large study published in JAMA Internal Medicine conducted in the UK, researchers report another possible factor: a group of drugs known as anticholinergics. These include prescription medications for treating depression, pulmonary disease, and Parkinson’s, as...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brain Dementia Drugs Source Type: news
Authors: Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K Abstract INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Esquiva G, Hannibal J Abstract Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modulation of the sleep/wake cycle. There are five subtypes of mRGCs differentiated by morphology and function. Recent years of research on mRGCs have identified a broad number of neurodegenerative diseases in the eye and the brain with altered physiologic light respon...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
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