Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener

Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Tianpeng Yin, Xiaofang Hu, Ruifeng Mei, Yan Shu, Dong Gan, Le Cai, Zhongtao Ding Four new C19-diterpenoid alkaloids, named taronenines A-D (1-4), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk medicine to treat rheumatism and arthritis in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects using LPS-stimulated RAW 264.7 macrophages. Compounds 1, 2 and 4 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 29.60 ± 0.08 μg/mL, 18.87 ± 0.14 μg/mL, and 25.39 ± 0.11 μg/mL, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research