A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells

Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential and ineffective treatment strategies result in persistent injuries and tissue that is unable to perform its normal phys...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: Available online 27 January 2020Source: Stem Cell ResearchAuthor(s): Chanchao Lorthongpanich, Chuti Laowtammathron, Nittaya Jiamvoraphong, Pimonwan Srisook, Pimjai Chingsuwanrote, Phatchanat Klaihmon, Nattaya Damkham, Papussorn Terbto, Supaporn Waeteekul, Yaowalak U-pratya, Surapol IssaragrisilAbstractYes-associated protein (YAP) is an important transcriptional coactivator in the Hippo signaling pathway. Using CRISPR/Cas9 technology, we established a stable YAP-knockdown (YAP-KD) induced pluripotent stem cell (iPSC) from the MUSIi012-A cell line. The YAP-KD iPSC MUSIi012-A-2 maintained the pluripotent phe...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Somuncu ÖS, Berns HM, Sanchez JG Abstract Optogenetics have recently increased in popularity as tools to study behavior in response to the brain and how these trends relate back to a neuronal circuit. Additionally, the high demand for human cerebral tissue in research has led to the generation of a new model to investigate human brain development and disease. Human Pluripotent Stem Cells (hPSCs) have been previously used to recapitulate the development of several tissues such as intestine, stomach and liver and to model disease in a human context, recently new improvements have been made in the field ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 26 January 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Sachchida Nand Rai, Payal SinghAbstractSince the discovery of L-dopa in the middle of the 20th century (1960s), there is not any neuroprotective therapy available although significant development has been made in the treatment of symptomatic Parkinson’s disease (PD). Neurological disorders like PD can be modelled in animals so as to recapitulates most of the symptoms seen in PD patients. In aging population, PD is the second most common neurodegenerative disease after Alzheimer’s disease, even though significant...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
As has been widely hyped for many years now, mesenchymal stem cells have the capacity to heal all sorts of damage in our bodies. The reality has been more complicated, since it is actually very difficult to get these cells to perform their magic just...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Medicine Nanomedicine Orthopedic Surgery Source Type: blogs
By 'rewinding' cells of early-onset Parkinson's disease patients back to their stem cell states, a Cedars-Sinai study found that, even as embryos, theyhad abnormal dopamine neurons.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by genome tiling arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Methylation profiling by genome tiling array Homo sapiens Source Type: research
Contributors : Matko Čančer ; Sonja Hutter ; Gabriela Rosén ; Anders Sundström ; Jignesh Tailor ; Alexandra Garancher ; Magnus Essand ; Robert J Wechsler-Reya ; Anna Falk ; Holger Weishaupt ; Fredrik J SwartlingSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensHow tumors develop or respond to therapies vary significantly among species. Here we report that medulloblastoma (MB) the most frequent malignant childhood brain tumor can develop from human hindbrain neuro-epithelial stem (hbNES) cells or induced pluripotent stem cell (iPSC)-derived NES (NES) cells via MYCN overexpression...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Contributors : Matko Čančer ; Sonja Hutter ; Gabriela Rosén ; Anders Sundström ; Jignesh Tailor ; Alexandra Garancher ; Magnus Essand ; Robert J Wechsler-Reya ; Anna Falk ; Holger Weishaupt ; Fredrik J SwartlingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow tumors develop or respond to therapies vary significantly among species. Here we report that medulloblastoma (MB) the most frequent malignant childhood brain tumor can develop from human hindbrain neuro-epithelial stem (hbNES) cells or induced pluripotent stem cell (iPSC)-derived NES (NES) cells via MYCN overexpr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
The use of genetics has been invaluable in defining the complex mechanisms of aging and longevity. Zebrafish, while a prominent model for vertebrate development, have not been used systematically to address questions of how and why we age. In a mutagenesis screen focusing on late developmental phenotypes, we identified a new mutant that displays aging phenotypes at young adult stages. We find that the phenotypes are due to loss-of-function in the non-classical cadherin celsr1a. The premature aging is not associated with increased cellular senescence or telomere length but is a result of a failure to maintain progenitor cel...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Genetics and Genomics Source Type: research
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