Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

AbstractViral infections cause at least 10% –15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genomeediting techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virusrelated carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the c hallenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
Source: Frontiers of Medicine - Category: General Medicine Source Type: research