Polypharmacology in the treatment of Chagas disease.

Polypharmacology in the treatment of Chagas disease.
Curr Med Chem. 2018 Apr 09;:
Authors: Aguilera E, Alvarez G, Cerecetto H, Gonzalez M
Abstract
The current treatment of Chagas disease is based on monopharmacology where the used drugs have limited efficacy and severe side effects. In order to overcome these limitations some tools have been described including development or isolation of new drugs, drug repositioning, and polypharmacology. Here we review the polypharmacology strategy where compounds belonging to different structural chemotypes were combined in order to affect different biochemical pathways of T. cruzi parasite. Therefore ergosterol biosynthesis inhibitors, anti-inflammatory agents, cardiac dysfunction drugs, trypanothione reductase inhibitors, vitamins, between others, were combined looking for new anti-Chagas treatment. Natural products were also used in the application of this strategy.
PMID: 29637852 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - April 9, 2018 Category: Chemistry Authors: Aguilera E, Alvarez G, Cerecetto H, Gonzalez M Tags: Curr Med Chem Source Type: research