Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe

The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR.

Source: Kidney International - April 12, 2018 Category: Urology & Nephrology Authors: Katharina Br ück, Kitty J. Jager, Carmine Zoccali, Aminu K. Bello, Roberto Minutolo, Kyriakos Ioannou, Francis Verbeke, Henry Völzke, Johan Arnlöv, Daniela Leonardis, Pietro Manuel Ferraro, Hermann Brenner, Ben Caplin, Philip A. Kalra, Christoph Wanner Tags: Clinical Investigation Source Type: research