The severity of neurocognitive impairment

(Bentham Science Publishers) Neurocognitive impairment is frequently encountered in multiple sclerosis patients affecting between 40-65 percent of these individuals, irrespective of disease duration, severity of physical disability, and at both the earlier and later disease stages, with a tendency to worsen over time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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In this study eight patients with RRMS were chosen and included in the trial. Patients received rapamycin (Rapacan, Biocon, India) for six months. Magnetic resonance imaging (MRI) of the patients’ brain was taken before and after the therapy. Patients’ expanded disability status scale (EDSS), and FoxP3 and GARP gene expression, and Treg cell proliferation were also been evaluated. All the patients had some degrees of significant reduction in mean plaque area size (P=0.012, Z=-2.520), and minimum and maximum size of the plaques (P=0.012, Z=-2.521). EDSS of 50% of patients was decreased after the treatment, yet i...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This cohort study examines the association of superimposed relapses in progressive-onset multiple sclerosis on disease outcomes.
Source: JAMA Neurology - Category: Neurology Source Type: research
ConclusionAbsence of post-training tDCS-induced facilitation of consolidation in patients with MS suggests that the interaction of tDCS with the motor consolidation network is inefficient. Identification of the underlying disease-related mechanisms will have important implications for the design of studies aiming to promote motor recovery in MS by non-invasive brain stimulation.
Source: Journal of Neurology - Category: Neurology Source Type: research
Authors: Masmoudi R, Aissi M, Halouani N, Fathallah S, Louribi I, Aloulou J, Amami O, Frih M Abstract OBJECTIVES: To compare the scores of the different dimensions of sexual function of women with multiple sclerosis to a group of control women and to identify possible factors associated with sexual dysfunction in women with multiple sclerosis. METHODS: This is a descriptive and analytical case-control study. Twenty-six women with multiple sclerosis were compared to 26 control women matched for age and socioeconomic status. The evaluation focused on demographic and clinical data. Patients with multiple sclerosis...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Authors: Cordano C, Armezzani A, Veroni J, Pardini M, Sassos D, Infante MT, Tacchino A, Lapucci C, Cellerino M, Calabrò V, Ciullo L, Nourbakhsh B Abstract Context: Research on the effect of osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) on chronic symptoms of multiple sclerosis (MS) is lacking. Objective: To evaluate the effect of OMTh on chronic symptoms of MS. Methods: Patients with MS who were evaluated at the neurology clinic at Genoa University in Italy were recruited for this study. Participants received 5 forty-minute MS health education sessi...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
ConclusionsRisk of death in MS varies substantially with degree of disability. This has important implications for clinical management and health economic modelling.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThis is the first study that provides epidemiological data on the prevalence and clinical forms of MS in Salta City as well as in the entire Northwest Region of Argentina(NOA). We estimate a prevalence of 23.8 cases per 100,000 inhabitants, which establishes a moderate risk area for MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Although multiple sclerosis (MS) is often diagnosed during young adulthood (18-30 years), there is a lack of knowledge on the psychological adjustment to the illness among recently diagnosed young adult patients.
Source: Disability and Health Journal - Category: Disability Authors: Source Type: research
Publication date: Available online 31 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Giancarlo Coghe, Giuseppe Fenu, Lorena Lorefice, Erica Zucca, Micaela Porta, Giuseppina Pilloni, Federica Corona, Jessica Frau, Maria Giovanna Marrosu, Massimiliano Pau, Eleonora CoccoAbstractIntroduction: Cognitive motor interference (CMI) is performance impairment due to simultaneuous task execution and is measured using the dual task cost (DTC). No pathological feature of MS has to date been associated with CMI.Aim: To assess the relationship between brain volumes and CMI, as measured using the DTC, in a cross-secti...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsOne-third of people with MS identified a need for mental health care. Symptoms of anxiety and depression, but not current diagnosed mental health disorders, were the predominant factors associated with a reported need for care.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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