Myositis: Are autoantibodies pathogenic in necrotizing myopathy?

Myositis: Are autoantibodies pathogenic in necrotizing myopathy?Myositis: Are autoantibodies pathogenic in necrotizing myopathy?, Published online: 12 April 2018; doi:10.1038/nrrheum.2018.54What causes muscle fibre necrosis in necrotizing myopathy? The authors of a new study propose that specific autoantibodies contribute to disease via immune-mediated processes; but given that these processes also occur in muscular dystrophies, how likely is that these antibodies trigger muscle fibre necrosis?

Source: Nature Reviews Rheumatology - April 12, 2018 Category: Rheumatology Authors: Marinos C. Dalakas Source Type: research