Safety and Efficacy of a Progressively Prolonged Maintenance Interval of Venom Immunotherapy
Conclusions: Progressively prolonging the VIT maintenance interval up to 26 weeks appears to be safe and efficacious.Int Arch Allergy Immunol
Identification of Api m 1 IgE epitopes and characterization of their mimotopes described herein represents an important step towards better understanding of sting anaphylaxis pathogenesis and towards development of alternative immunotherapy for bee venom allergy.
The severity of allergic reactions to insect stings ranges from mild, local reactions to systemic, life-threatening anaphylaxis.1, 2 Systemic reactions (SRs) to Hymenoptera stings can occur in 0.5-3.3% of adults in the US and 0.3-7.5% of adults in Europe.3, 4 In pediatric patients, the prevalence of SRs is lower, from 0.15-0.8%.5-8 In addition, in children, the majority of SRs from sting consist of exclusively cutaneous symptoms.9 Venom immunotherapy (VIT) is very effective in decreasing the SR risk after subsequent sting and is generally indicated in subjects with histories of SRs to Hymenoptera stings with extra-cutaneous symptoms.
ConclusionsLooking at this selected population, we suggest that mastocytosis should be considered in patients developing severe reactions at re-sting after VIT discontinuation and, as a speculation, patients with mastocytosis and HVA should be VIT-treated lifelong.
Stings by Hymenoptera insects are relatively common in the general population and may cause different symptoms ranging from mild and local reactions to life-threatening and fatal anaphylaxis.1
Stings by Hymenoptera insects are relatively common in the general population and may cause different symptoms, ranging from mild and local reactions to life-threatening and fatal anaphylaxis.1
DEPOT EXTRACTS FOR RUSH VENOM IMMUNOTHERAPY: A NEW THERAPEUTIC OPPORTUNITY FOR HYMENOPTERA STING ALLERGY. Ann Allergy Asthma Immunol. 2018 Jun 13;: Authors: Pucci S, Ciccarelli F, De Pasquale T, Illuminati I, D'Alò S PMID: 29908318 [PubMed - as supplied by publisher]
AbstractPurpose of reviewUnaware of the natural history of large local reactions caused by Hymenoptera stings, patients and clinicians are often concerned when faced with these reactions. These concerns include the difficulty in avoiding stings, the local discomfort, and the fear that the local reaction portends systemic, potentially life-threatening subsequent reactions. This review presents the historical studies that have assessed the natural history of large local reactions caused by Hymenoptera stings and, in doing so, provides rationale for the current consensus guidelines for the management of these reactions.Recent...
Purpose of review Recognize the presentation of anaphylaxis for prompt management and treatment and to provide tools for the diagnosis of the underlying cause(s) and set up a long-term treatment to prevent recurrence of anaphylaxis. Recent findings The recent description of phenotypes provides new insight and understanding into the mechanisms and causes of anaphylaxis through a better understanding of endotypes and biomarkers for broad clinical use. Summary Anaphylaxis is the most severe hypersensitivity reaction and can lead to death. Epinephrine is the first-line treatment of anaphylaxis and it is life-saving. Pa...
Şahiner ÜM Abstract BACKGROUND: Venom immunotherapy (VIT) is safe in children, although adverse effects can occur. OBJECTIVE: To document adverse effects and to determine re-sting reactions and the efficacy of VIT in childhood. METHODS: We retrospectively analyzed data from children who had taken VIT from 2002 through 2015. These patients were queried by telephone to determine reactions after re-stings during or after VIT. RESULTS: In total 107 children with a systemic reaction after Hymenoptera sting and with proved immunoglobulin E-mediated sensitization were enrolled. Participants had a me...
Systemic mastocytosis (SM) is a disorder caused by the abnormal proliferation of mast cells (MCs) in one or more organs, leading to heterogeneous clinical presentations. SM patients are more at risk for hymenoptera-sting-induced anaphylaxis1 and in these patients indolent systemic mastocytosis (ISM) is the most frequent form of this disorder.