Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNF α-induced apoptosis via increased Bnip3-related mitophagy.

Conclusions: After TNFα-induced inflammatory injury, MA-5 affects microglial mitochondrial homeostasis in a manner mediated via the amplification of protective, Bnip3-related mitophagy, which is mediated via the MAPK-ERK-Yap signaling pathway. PMID: 29636771 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29636771?dopt=Abstract

Source: Cellular and Molecular Biology Letters - April 12, 2018 Category: Biochemistry Authors: Lei Q, Tan J, Yi S, Wu N, Wang Y, Wu H Tags: Cell Mol Biol Lett Source Type: research