Innovation in Cell Banking, Expansion, and Production Culture.

Innovation in Cell Banking, Expansion, and Production Culture.
Adv Biochem Eng Biotechnol. 2018 Apr 11;:
Authors: Kshirsagar R, Ryll T
Abstract
Cell culture-based production processes enable the development and commercial supply of recombinant protein products. Such processes consist of the following elements: thaw and initiation of culture, seed expansion, and production culture. A robust cell source storage system in the form of a cell bank is developed and cells are thawed to initiate the cell culture process. Seed culture expansion generates sufficient cell mass to initiate the production culture. The production culture provides an environment where the cells can synthesize the product and is optimized to deliver the highest possible product concentration with acceptable product quality. This chapter describes the significant innovations made in these process elements and the resulting improvements in the overall efficiency, robustness, and safety of the processes and products.
PMID: 29637222 [PubMed - as supplied by publisher]

Source: Advances in Biochemical Engineering Biotechnology - April 11, 2018 Category: Biotechnology Authors: Kshirsagar R, Ryll T Tags: Adv Biochem Eng Biotechnol Source Type: research