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FDA proposes new path to 510(k) clearance

The U.S. Food and Drug Administration (FDA) has proposed a new pathway for...Read more on AuntMinnie.comRelated Reading: FDA authorizes ACR to accredit DBT devices FDA releases update on breast implant lymphoma risk FDA: Brain coils may cause artifacts on MRA images FDA clears blood test to assist concussion evaluation FDA updates policy for nixing 510(k) submissions
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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CONCLUSION: Our observations highlight the difficulty to diagnose this complication with often non-specific clinical presentation and possible delayed occurrence after to transplantation, but also the therapeutic challenges, defibrotide being the only agent currently efficient. Physiopathology and potential responsibility of bendamustine in the sinusoidal obstruction syndrome occurrence will be discussed. PMID: 29673920 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Immunodeficiency, whether congenital or acquired, iatrogenic (e.g. allograft recipients) or infectious (e.g. human immunodeficiency virus (HIV)), is associated with an increased risk of malignancy. In the case of HIV infection, most cancers are associated with oncogenic virus infection. Although the overall risk of any cancer is increased 2 –3-fold in people living with HIV, there are three acquired immune deficiency syndrome (AIDS)-defining cancers whose relative risk is dramatically higher. These three AIDS-defining illnesses are Kaposi's sarcoma, high-grade B cell non-Hodgkin's lymphoma (including primary cerebral...
Source: Medicine - Category: Internal Medicine Authors: Tags: HIV and its complications Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractIn our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56.3%) in partial remission (PR), and five (31.2%) with active disease. The patients were transplanted from an HLA-identical (n = 7) from a mismatched (n = 1) or haploidentical (n = 1) sibling, from matched unrelated donor (n = 5), or from a single cord blood unit (n = 2). Conditioning regimen was standard myeloablative in 6 pa...
Source: Annals of Hematology - Category: Hematology Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractThe geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI
Source: Annals of Hematology - Category: Hematology Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractRecent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients. PFS was evaluated accordingly to Kaplan-Meier method. Higher NLR was associated to ad...
Source: Annals of Hematology - Category: Hematology Source Type: research
Authors: Jin S, Lee HS, Jeong JY, Jo YW Abstract Follicular lymphomas, which typically arise in the lymph nodes with spleen, liver, and bone marrow involvement, have generally low occurrence rates in Asian countries as compared with Western countries. Follicular lymphomas of the gastrointestinal tract are rare, and primary colonic follicular lymphomas are particularly rare compared with others found in the small intestine and duodenum. Colonoscopic imaging of colonic lymphomas, including follicular lymphoma, may reveal mucosal ulcerations, erosions, indurations, polypoid mass-like lesions, and diffuse mucosal nodul...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Was on opioids previously for various pains, but became addicted and overtook and used her friend's pills etc H/o ER admission for suicidality, withdrawl, etc. Coming to see me monday Currently on Norco 5's 2 tablets every 4 hours for what she describes as diffuse bony pain. PET scan shows lypmh nodes lighting up in the neck/mediastinum/groin On high dose chemo and going to undergo bone marrow transplant after it. What would you do? Appreciate in advance any advice in this delicate... 31yo Stg IV Lymphoma Pt with h/o opioid abuse and psych history
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
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