Postmarketing Adverse Event Reporting for Medical Products and Dietary Supplements During an Influenza Pandemic

Drug Safety
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Source Type: news

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Publication date: Available online 10 October 2018Source: Sensors and Actuators B: ChemicalAuthor(s): K. Siuzdak, P. Niedziałkowski, M. Sobaszek, T. Łęga, M. Sawczak, E. Czaczyk, K. Dziąbowska, T. Ossowski, D. Nidzworski, R. BogdanowiczAbstractNew rapid pathogen detection methods with improved cost-effectiveness and efficiency are currently in the focus of the scientists from all over the world. Based on the experiences from the rapid spread of the influenza virus pandemic in 2009 it is clear that the development of the system for early diagnosis of this infection is essential. The crucial stage of the treatment is the...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
PMID: 30303733 [PubMed - in process]
Source: American Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Am J Public Health Source Type: research
Too Many Patients…A Framework to Guide Statewide Allocation of Scarce Mechanical Ventilation During Disasters. Chest. 2018 Oct 11;: Authors: Daugherty Biddison EL, Faden R, Gwon HS, Mareiniss DP, Regenberg AC, Schoch-Spana M, Schwartz J, Toner ES Abstract The threat of a catastrophic public health emergency causing life threatening illness or injury on a massive scale has prompted extensive federal, state, and local preparedness efforts. Modeling studies suggest that an influenza pandemic similar to that of 1918 would require ICU and mechanical ventilation capacity that is significantly greater...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Publication date: Available online 10 October 2018Source: EpidemicsAuthor(s): Stephen M. Kissler, Julia R. Gog, Cécile Viboud, Vivek Charu, Ottar N. Bjørnstad, Lone Simonsen, Bryan T. GrenfellAbstractA key issue in infectious disease epidemiology is to identify and predict geographic sites of epidemic establishment that contribute to onward spread, especially in the context of invasion waves of emerging pathogens. Conventional wisdom suggests that these sites are likely to be in densely-populated, well-connected areas. For pandemic influenza, however, epidemiological data have not been available at a fine eno...
Source: Epidemics - Category: Epidemiology Source Type: research
Capacity building for influenza is critical because if you can prepare for and respond to flu outbreaks or respiratory events, you learn and practice for responses to other emerging diseases. Flu is not a sporadic outbreak like Ebola or Zika. It is always there, so there is always something to practice with and keep skills sharp. Because flu is a continual threat there is a lot of learning that goes on which also supports work on other emerging diseases. It ’s like the basic architecture for capacity building in all areas. For example, you can practice your communications for responding to outbreaks and better unders...
Source: WHO Feature Stories - Category: International Medicine & Public Health Tags: immunization [subject], vaccination, influenza [subject], flu, seasonal influenza, pandemic influenza Source Type: news
We aimed to describe the factors associated with antibiotic use in upper respiratory tract infections (URTI) in post-pandemic influenza period.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
AbstractInfluenza remains an important threat for human health, despite the extensive study of influenza viruses and the production of effective vaccines. In contrast to virus genetics determinants, host genetic factors with clinical impact remained unexplored until recently. The association between three single nucleotide polymorphisms (SNPs) and influenza outcome in a European population was investigated in the present study. All samples were collected during the influenza A(H1N1)pdm09 post-pandemic period 2010 –11 and a sufficient number of severe and fatal cases was included. Host genomic DNA was isolated from ph...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift, thereby limiting vaccine efficacy. Bypassing the immune system’s tendency to focus on the most variable regions of the HA may be a step toward more broadly protective influenza vaccines. However, this requires a better understanding of the biological meaning of immunodominance, and of the hierarchy between different antigenic sites. In this issue of the JCI, Liu et al. ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
(InDevR, Inc.) To help prevent or mitigate the severity of a potentially devastating influenza pandemic, public health agencies and vaccine manufacturers must be able to rapidly define, develop, manufacture, and release 'pandemic' vaccines. To address these shortcomings of SRID, InDevR developed the VaxArray Influenza Pandemic HA Potency Assay (VXI-pHA).
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Abstract Bird to human transmission of high pathogenicity avian influenza virus (HPAIV) poses a significant risk of triggering a flu pandemic in the human population. Therefore, vaccination of susceptible poultry during an HPAIV outbreak might be the best remedy to prevent such transmissions. To this end, suitable formulations and an effective mass vaccination method that can be translated to field settings needs to be developed. Our previous study in chickens has shown that inhalation of a non-adjuvanted dry powder influenza vaccine formulation during normal breathing results in partial protection against lethal ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Biopharm Source Type: research
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