Postmarketing Adverse Event Reporting for Medical Products and Dietary Supplements During an Influenza Pandemic

Drug Safety
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Source Type: news

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acute;nez-Sobrido Influenza virus still represents a considerable threat to global public health, despite the advances in the development and wide use of influenza vaccines. Vaccination with traditional inactivate influenza vaccines (IIV) or live-attenuated influenza vaccines (LAIV) remains the main strategy in the control of annual seasonal epidemics, but it does not offer protection against new influenza viruses with pandemic potential, those that have shifted. Moreover, the continual antigenic drift of seasonal circulating influenza viruses, causing an antigenic mismatch that requires yearly reformulation of seasona...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Source: World Health Organization (WHO). Published: 2/21/2019. This 10-page document summarizes the genetic and antigenic characteristics of recent zoonotic influenza viruses and related viruses circulating in animals that are relevant to influenza candidate vaccine virus updates. Zoonotic influenza viruses continue to be identified and evolve both genetically and antigenically, leading to the need for additional candidate vaccine viruses for pandemic preparedness purposes. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
(Natural News) A new report is urging government officials to begin stockpiling antibiotics in preparation for a potential global influenza pandemic, claiming that doing so will ultimately end up saving authorities tens of billions of dollars. The first study yet to model the financial value of stockpiling antibiotics, the analysis claims that the world can...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
As a leading cause of respiratory disease, influenza A virus (IAV) infection remains a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapeutic drugs, developme...
Source: Virology Journal - Category: Virology Authors: Tags: Research Source Type: research
ahesh Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 subtypes, which pose a threat to public health. Treatment options are limited and emergence of strains resistant to antiviral drugs jeopardize this even further. Like all viruses, IAVs depend on host factors for every step of the virus replication cycle. Host kinases link multiple signaling pathways ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
ConclusionInfluenza vaccination is immunologically active for AIRD, with little value of the second dose of the pandemic vaccine and further scrutiny on persistence of immune response to vaccine in AIRD  is needed.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
(Center for Disease Dynamics, Economics&Policy) In a new study published in the journal Health Economics, researchers at CDDEP, the University of Strathclyde in Scotland, and Wageningen University in the Netherlands developed a mathematical framework to estimate the value of investing in developing and conserving an antibiotic to mitigate the burden of bacterial infections caused by resistant Staphylococcus aureus during a pandemic influenza outbreak.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
In this study, we hypothesized that identifying mutation positions in all segments (proteins) encoded by the influenza genome would enable pandemic and seasonal strains to be more reliably distinguished. In a large scale study, we applied a range of data mining techniques to all segments of influenza for rule discovery and discrimination of pandemic from seasonal strains. CBA (classification based on association rule mining), Ripper and Decision tree algorithms were utilized to extract association rules among mutations. CBA outperformed the other models. Our approach could discriminate pandemic sequences from seasonal ones...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
One hundred years ago, the devastating 1918–1919 Spanish influenza pandemic took the lives of 50 to 100 million people, or 3 to 5% of the world population (1). Influenza A virus (IAV) pandemics occur when an animal IAV crosses the species barrier, usually by acquiring a new genetic trait by...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Commentaries Source Type: research
In this study, we developed and tested a new HA quantitative enzyme-linked immunosorbent assay (ELISA) using a universal monoclonal antibody that can bind to HAs from various subtypes in group 1 influenza A virus (IAV). We analyzed the conserved stalk domain of HA via a library approach to design a consensus HA antigen for group 1 IAV. The antigens were expressed as a soluble form in E. coli and were purified by Ni-affinity chromatography. When tested with variety of HAs from IAVs or influenza B viruses (IBVs), the mAbs exhibited specific binding to group 1 HAs, with potential exception to H9 subtype. Among various conditi...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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