Long noncoding RNA: multiple players in gene expression.

Long noncoding RNA: multiple players in gene expression.
BMB Rep. 2018 Apr 11;:
Authors: Chen X, Sun Y, Cai R, Wang G, Shu X, Pang W
Abstract
Previously considered as a component of transcriptional noise, long noncoding RNAs ( lncRNAs) were neglected as a therapeutic target, however, recently increasing evidence has shown that lncRNAs can participate in numerous biological processes involved in genetic regulation including epigenetic, transcriptional, and post-transcriptional regulation. In this review, we discuss the fundamental functions of lncRNAs at different regulatory levels and their roles in metabolic balance. Typical examples are introduced to illustrate their diverse molecular mechanisms. The comprehensive investigation and identification of key lncRNAs will not only contribute to insights into diseases, such as breast cancer and type II diabetes, but also provide promising therapeutic targets for related diseases.
PMID: 29636120 [PubMed - as supplied by publisher]

Source: BMB Reports - April 11, 2018 Category: Biochemistry Authors: Chen X, Sun Y, Cai R, Wang G, Shu X, Pang W Tags: BMB Rep Source Type: research