Comorbid Insomnia and Psychiatric Disorders: An Update

This article reviews this relationship and provides recommendations for management. Keywords: Insomnia, sleep disorder, psychiatric disorder, depression, psychosis, schizophrenia, anxiety disorder Insomnia affects 25 million people in the United States annually and leads to an estimated $100 billion health care burden. Insomnia has also been shown to be a causal factor in other medical and psychiatric disorders, cognitive impairments, accidents, absenteeism, and reduced quality of life.1 The cost of not treating insomnia is more than the cost of treating insomnia.2 Insomnia as a symptom is seen in up to one third of the United States population, while the disorder is seen in up to 20 percent.3 The diagnostic criteria of insomnia have been updated in the International Classification of Sleep Disorders, Third Edition (ICSD-3) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The distinction between primary and secondary insomnia was removed from both classifications. Insomnia is a disorder unto itself that needs independent clinical attention. Viewing insomnia mainly as a symptom of another disorder prompted many clinicians to direct the bulk of their treatment efforts at the so-called primary disorder. Studies have shown that treating insomnia leads to better outcomes and improvement in co-existing psychiatric disorders.  To achieve optimal treatment outcomes in people with comorbid psychiatric illness and insomnia, the clinician should...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review anxiety disorder depression insomnia psychiatric disorder psychosis schizophrenia sleep disorder Source Type: research

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Mesenchymal stem cell therapy for heart failure: a meta-analysis. Herz. 2018 Oct 19;: Authors: Fu H, Chen Q Abstract BACKGROUND: Mesenchymal stem cell (MSC) treatment has emerged as an important adjunct therapy for heart failure. However, the use of MSC to treat heart failure has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of MSC treatment for heart failure. METHODS: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials (RCTs) assessing the influence of MSC treatment on ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Rachael Horne, Jane A. Foster
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
The public health burden of alcohol use disorder is experienced globally, yet the heterogeneous clinical presentation of this disorder and the spectrum of pathophysiology associated with its various disease stages have made it difficult —despite auspicious animal models—to bring forth efficacious pharmacotherapies that improve clinical outcome. This particularly complex field of therapeutic drug development calls for better strategies to expand drug targets and to optimize their use.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
During the time that this remarkable drug is relieving pain a very curious psychical condition manifests itself; namely, that the diminution of the pain seems to be due to its fading away in the distance, so that the pain becomes less and less, just as the pain in a delicate ear would grow less and less as a beaten drum was carried farther and farther out of the range of hearing. This condition is probably associated with the other well-known symptom produced by the drug; namely, the prolongation of time.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Clinical Commentary Source Type: research
The report finds that many existing policies and regulations aimed at tackling food marketing to children are markedly insufficient.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
AbstractPrevious association studies have demonstrated the association between immune regulatory genes and suicide behavior. Among these genes are those coding for cytokines. In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. The rs2069845 was not associated with suicide behavior. The rs1800795 C allele was significantly more common among suicide completers compared with suicide attempters (OR (95% CI)  = 1.33 (1.04–1.71)), a...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Authors: Sohliya L, Mathew J, Ishitha G, Panwar J, Jacob KM Abstract Rheumatoid Arthritis can present with consistent pain over peripheral joints. The manner of presentation of a subcutaneous tumour such as Myopericytoma may be very similar to that of an inflamed joint leading to the high frequency of it being overlooked and inadequately treated. Knowing the radiological and pathological differences will direct us in the right road to timely and adequate treatment. PMID: 30341880 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Ansari MZ, Tolstoy R, Jagadeeswaran G Abstract Thrombocytopenia is a common complication in patients with chronic liver disease and is multi-factorial. It complicates the management and worsens the prognosis. Treatment options are costly and include platelet transfusion, splenectomy, splenic artery embolization, TIPPS and thrombopoietin (TPO) agonists. Here we are presenting a patient with decompensated liver disease with known chronic alcoholism and profound thrombocytopenia despite multiple platelet transfusions. On further work up we found a coexistent autoimmune etiology. Thrombocytopenia promptly resp...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
This article attempts to explore data on role of rosuvastatin for secondary prevention. PMID: 30341873 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Snehalatha C, Priscilla S, Nanditha A, Arun R, Satheesh K, Ramachandran A Abstract Identification and treatment of individuals with prediabetes is crucial. Effective interventional strategies are key to reducing the diabetes risk at the population level. Lifestyle intervention is found to be more effective but more expensive. Evidence of potential benefits from pharmacotherapy is accumulating. The choice of a pharmacologic intervention to reduce the progression of type 2 diabetes (T2DM) in high risk individuals must consider the balance between the benefit to risk ratio. A meta-analysis of the results of t...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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