Angiopoietin-2, Renal Deterioration, Major Adverse Cardiovascular Events and All-Cause Mortality in Patients with Diabetic Nephropathy

Conclusion: Angpt2 is an independent predictor of adverse clinical outcomes in diabetic patients. Further studies are needed to identify the pathogenic role of Angpt2 in renal deterioration and cardiovascular complications of diabetes mellitus.Kidney Blood Press Res 2018;43:545 –554
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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AbstractPurpose of ReviewThe choice of optimum transplant in a patient with type 1 diabetes mellitus (T1DM) and chronic kidney disease stage V (CKD V) is not clear. The purpose of this review was to investigate this in more detail —in particular the choice between a simultaneous pancreas-kidney transplantation (SPKT) and living donor kidney transplantation (LDKT), including recent evidence, to aid clinicians and their patients in making an informed choice in their care.Recent FindingsAnalyses of large databases have recently shown SPKT to have better survival rates than a LDKT in the long-term, despite an early incre...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Conclusions: CD146 is associated with kidney injury and could be a good marker to predict renal outcomes in patients with early stages of DN.Cell Physiol Biochem 2018;48:63 –74
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Till Keller, Christoph Wanner, Vera Krane, Daniel Kraus, Bernd Genser, Hubert Scharnagl, Winfried März, Christiane DrechslerBackgroundMortality is high among patients undergoing hemodialysis for whom cardiac troponin concentration is a strong predictor of outcome. Modern troponin assays allow measurement of very low concentrations.Study DesignUsing data from a randomized controlled trial, a cohort analysis to evaluate the prognostic value of very low cardiac troponin T (TnT) concentrations.Setting &Participants1,25...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
DiscussionTime frame from diabetic nephropathy to ESRF among Malaysian population was shorter as compared to findings from other countries with an average period of 15 to 25 years. RAAS blockers should be initiated early in diabetic patients.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 22 May 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Nicolas Roberto Robles, Juan Lucio Ramos, Edgar Chavez, Boris Gonzalez Candia, Miguel Angel Bayo, Antonio Cidoncha, Juan Lopez Gomez, Juan Jose CuberoAbstractBackgroundsIron deficiency has been studied extensively in patients with chronic kidney disease on hemodialysis therapy. However, few studies looked at iron treatment in the non-dialysis chronic kidney disease population.MethodsFive hundred and eighty patients were studied (247 were diabetic persons). Patients were divided into 4 groups: non...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionRAAS blockers usage among T2DM patients was higher in primary care versus tertiary care settings. Majority of the patients did not receive optimal dose of RAAS blockers.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: May 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 12, Issue 3Author(s): Alok Raghav, Jamal AhmadAbstractNephropathy in diabetes patients is the most common etiology of end-stage kidney disease (ESKD). Strict glycemic control reduces the development and progression of diabetes-related complications, and there is evidence that improved metabolic control improves outcomes in subjects having diabetes mellitus with advanced chronic kidney disease (CKD). Glycemic control in people with kidney disease is complex. Changes in glucose and insulin homoeostasis may occur as a co...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 20 June 2018Source: Canadian Journal of DiabetesAuthor(s): Adame Perez SI, Senior PA, Field CJ, Jindal K, Mager DRAbstractBackgroundFrailty can cause an increased vulnerability to adverse health outcomes such as falls, fractures, depression and reduced health related quality of life (HRQoL). This cross sectional study compared differences in body composition, HRQoL, mental health, cognitive and vitamin D (VitD) status and health care utilization between frail and non-frail adults with Diabetes Mellitus (DM Type 1 and Type 2) with chronic kidney disease (CKD stages 1-5).Methods and Partici...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
DiscussionTime frame from diabetic nephropathy to ESRF among Malaysian population was shorter as compared to findings from other countries with an average period of 15 to 25 years. RAAS blockers should be initiated early in diabetic patients.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
DiscussionTime frame from diabetic nephropathy to ESRF among Malaysian population was shorter as compared to findings from other countries with an average period of 15 to 25 years. RAAS blockers should be initiated early in diabetic patients.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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