It's Tick Season -- Know Your Enemy

So many ticks are lurking in the brush and woodlands. Here's what they might give you. It's more than Lyme.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Authors: Fukushima K, Yanagisawa N, Kawabata H, Yajima K PMID: 30996189 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 18 April 2019Source: Veterinary MicrobiologyAuthor(s): Min-Goo Seo, Oh-Deog Kwon, Dongmi KwakAbstractA 23-year-old male Thoroughbred horse at the Korean Military Academy appeared thin with visible rib bones and presented clinical signs of fever, anorexia, lethargy, and severe dehydration. To determine the presence of various febrile disease-causing agents, the 23 cohabiting horses at the academy, including this horse, were subjected to hematology, blood chemistry, and molecular analysis using whole blood samples collected during regular medical check-ups. On the basis of clinical history,...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 18 April 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Eliza A.H. Little, John F. Anderson, Kirby C. Stafford, Lars Eisen, Rebecca J. Eisen, Goudarz MolaeiAbstractLyme disease is the most prevalent vector-borne disease in the United States. Ixodes scapularis, commonly referred to as the blacklegged tick, is the primary vector of Lyme disease spirochetes, Borrelia burgdorferi sensu lato (s.l.), in the eastern United States. Connecticut has pervasive populations of I. scapularis and remains a hotspot for Lyme disease. A primary aim of this study was to determine if passively collected...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Source: ScienceNOW - Category: Science Authors: Tags: Epidemiology, Medicine, Diseases In Depth Source Type: news
In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
John R. Caskey1,2†, Nicole R. Hasenkampf1, Dale S. Martin1, Vladimir N. Chouljenko2, Ramesh Subramanian2, Mercedes A. Cheslock1 and Monica E. Embers1* 1Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, LA, United States 2Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, United States Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in the presence of microbiostatic drugs such as doxycycline. Precisely how this...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: July 2019Source: Biomedicine &Pharmacotherapy, Volume 115Author(s): Hua Zhao, Xiting Dai, Xinlin Han, Aihua Liu, Fukai Bao, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Manzama-Esso Abi, Taigui Chen, Lisha Luo, Mingbiao Ma, Lvyan TaoAbstractLyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an importa...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study provides insight into the microbial diversity of I. scapularis in New York State and Connecticut.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Knowing the frequency of positive Lyme disease serology in children without signs of infection facilitates test interpretation. Of 315 asymptomatic children from Lyme disease endemic regions, 32 had positive or equivocal C6 enzyme-linked immunoassays, but only 5 had positive IgG or IgM supplemental immunoblots (1.6%; 95% confidence interval: 0.7%–3.7%).
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
Charlotte Mason1, Xiaoyan Liu2, Spoorthy Prabhudeva1 and Zhiming Ouyang1* 1Department of Molecular Medicine, University of South Florida, Tampa, FL, United States 2Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States BosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. Unlike typical Fur proteins in which DNA binding represses gene expression, binding of BosR to the rpoS promoter directly activates rpoS transcription in B. burgdorferi. However, virtually nothing is known concerning potential structural fea...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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