Soterix touts transcranial stim depression trial results

Soterix Medical today released results from trials of its direct current stimulation-limited total energy technology designed to treat depression, touting that the device was found to be safe and effective with improvements in depression-rating metrics lasting for a month after treatment. The tDCS-LTE system is designed to deliver energy to the dorsolateral prefrontal cortex region of the brain which is implicated in depression control, the New York-based company said. In the first trial, the company reported that its tDCS-LTE system was effective and safe as an add-on intervention for patients with type I or II bipolar disorder during major depressive episodes who are being treated with pharmaceuticals. Data from the 59-patient trial indicated that treatment with the system resulted in a 14-point improvement in the Hamilton Depression Rating scale after 12 treatments, with benefits persisting for over a month. Side effects were found to be no different from placebo, the company added. Results from the first trial were published in the journal JAMA Psychiatry. In the second trial, which enrolled 245 patients, researchers reported that treatment with the tDCS-LTE was superior to placebo, resulting in an 8 point improvement on the HDR scale after 15 weekday treatments followed by seven tapered weekly treatments. Patients treated with the tDCS-LTE group reported higher rates of itching, tingling, tinnitus and nervousness than other groups, while groups receiving only escitalopra...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Neurological Neuromodulation/Neurostimulation Soterix Medical Source Type: news

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Publication date: Available online 20 July 2018Source: Journal of the Formosan Medical AssociationAuthor(s): Ching-Fang Chang, Kuo-Hsuan Chung
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
The objective of the article was to review the beneficial effects of exercise in depression. An electronic search of literature from inception till 06/2017 highlighting the effects of exercise on depression and the possible mechanistic pathways involved was conducted using PubMed/Medline, Google scholar and Scopus and relevant articles were utilized for this review. The results of this review confirmed the beneficial role of exercise in depression as evidenced by the improvement in the outcomes and the various psychobiological parameters measured. Thus exercise can be considered as a treatment option for the management of depression.
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
Adapted from Understanding Antidepressants. In his often-quoted beginning of Anna Karenina, Tolstoy wrote, “All happy families are alike; each unhappy family is unhappy in its own way.”  If we stretch this notion a little — going from families to individuals, and from unhappiness to depression — we come up with an interesting question, which is the subject of this blog: Are persons with depression all alike, or is each depressed in his/her own way?  In one sense, the answer seems to be that the difficult experience of depression is unique to each person, affected by age, past experiences, ...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs
Publication date: September 2018Source: Research in Developmental Disabilities, Volume 80Author(s): Stephen Gallagher, Monika Pilch, Ailish HanniganAbstractPredictors of depression over time were examined in parental carers of children with developmental disabilities (DD) and parents of typically developing children (controls) who participated in the Growing up in Ireland Study. Parents completed measures of depression, the Centre for Epidemiological Depression Scale (CES-D) and child problem behaviours, the Strength and Difficulties Questionnaire when the children were aged 9 (Wave 1) and 13 (Wave 2). Using CES-D cut-off ...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: 15 October 2018Source: Materials Letters, Volume 229Author(s): J.T. Liang, J.M. Song, X.H. Dai, Y.S. Zhang, X.F. Liu, X.B. Li, J. Zhang, X.D. Meng, L. Zhao, B.T. LiuAbstractThe Pt/BiFeO3/La0.5Sr0.5CoO3/STO (Pt/BFO/LSCO/STO) heterojunction capacitors were fabricated on (1 1 0) SrTiO3 (STO) substrates by off-axis RF magnetron sputtering. The structure and physical properties of BiFeO3 thin films were investigated. It was found that the BFO film showed single phase (1 1 0) epitaxial perovskite structure with high crystal quality. The Pt/BFO/LSCO capacitor exhibited a saturated butterfly loop and a st...
Source: Materials Letters - Category: Materials Science Source Type: research
CONCLUSIONS: This prospective study confirms the predictive value of normal CTT and normal resting pressure, in the evolution towards spontaneous faecal continence. If CTT is abnormal, irrespective of the ARM, bowel management will be necessary to obtain pseudo-continence. In these cases, ARM is not a designated examination. PMID: 30024699 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Conclusion: Losartan might prevent axonal sprouting after hearing loss by blocking TGF-β signaling thereby preventing maladaptive auditory-somatosensory plasticity. PMID: 30021416 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research
CONCLUSIONS: Scurvy is a re-emerging disease, also in western countries. When purpura appears in young adults, scurvy has to be investigated, especially when a history of malnutrition is present. The treatment with vitamin C infusions should be started as soon as possible in order to prevent any complications. PMID: 30024630 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA. PATIENTS AND METHODS: We examined thirty-eight (38) patients (27 men, 11 women) with coexisting COPD and OSA - overlap syndrome (Group 1) vs. 38 patients with OSA-only (Group 2), matched for sex, age, and Body Mass Index (BMI). All patients underwent pulmonary function tests (PFTs), oximetry and overnight polysomnography and were asked about other coexisting chronic diseases and medications. RESULTS: Th...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Wu KK, Armstrong AW Abstract Psoriasis is a chronic inflammatory skin disease with under-investigated and underappreciated links to psychiatric comorbidities, including anxiety, depression, and suicidality. In this review, we synthesize and discuss the literature investigating the association between psoriasis and three measures of suicidality: suicidal ideation, suicide attempts, and completed suicide. Studies have shown that psoriasis is significantly linked to all three measures of suicidality, but the available data on suicide attempts and completed suicides is limited and less consistent. Studied risk...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
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