Soterix touts transcranial stim depression trial results

Soterix Medical today released results from trials of its direct current stimulation-limited total energy technology designed to treat depression, touting that the device was found to be safe and effective with improvements in depression-rating metrics lasting for a month after treatment. The tDCS-LTE system is designed to deliver energy to the dorsolateral prefrontal cortex region of the brain which is implicated in depression control, the New York-based company said. In the first trial, the company reported that its tDCS-LTE system was effective and safe as an add-on intervention for patients with type I or II bipolar disorder during major depressive episodes who are being treated with pharmaceuticals. Data from the 59-patient trial indicated that treatment with the system resulted in a 14-point improvement in the Hamilton Depression Rating scale after 12 treatments, with benefits persisting for over a month. Side effects were found to be no different from placebo, the company added. Results from the first trial were published in the journal JAMA Psychiatry. In the second trial, which enrolled 245 patients, researchers reported that treatment with the tDCS-LTE was superior to placebo, resulting in an 8 point improvement on the HDR scale after 15 weekday treatments followed by seven tapered weekly treatments. Patients treated with the tDCS-LTE group reported higher rates of itching, tingling, tinnitus and nervousness than other groups, while groups receiving only escitalopra...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Neurological Neuromodulation/Neurostimulation Soterix Medical Source Type: news

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Publication date: 20 December 2018Source: Sensors and Actuators B: Chemical, Volume 277Author(s): Tianlin Wang, Zhanhui Tao, Yanlong Lyu, Pengcheng Qian, Yunfei Li, Xiaodong Lin, Shuo Wang, Yaqing LiuAbstractHighly sensitive detection of cysteine is critical for early warning and diagnosis of cysteine-associated diseases. For the first time, herein, a reusable and ratiometric fluorescent biosensor with simple operation was developed for sensitive and rapid detection of Cys on the basis of configuration transformation of guanine-rich DNA (G-DNA). The sensing system is quite simple and consisted of G-DNA and Ag+ with NMM (N-...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Authors: Rana AQ, Qureshi ARM, Haris A, Danish MA, Furqan MS, Shaikh O, Sarfraz Z, Rana R Abstract OBJECTIVE: Pain is an important non-motor symptom of Parkinson's disease (PD); however, it remains understudied. The purpose of previous studies on the relationship between PD and pain, has been to explore the cause, origin and types of pain. This case control study is designed for clinicians and rehabilitation specialists to effectively identify pain from the patient's point of view. Pain present in PD patients correlates with significant disruption to their daily lives, which was seen by analysing characteristics, f...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
(MedPage Today) -- Also, how should hospital quality be assessed?
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
CONCLUSIONS: Psychiatric intervention of soldiers who present to a general hospital ED because of emotional difficulties may provide the opportunity for crisis intervention and validation of the soldier's distress. To the best of our knowledge this is the first Israeli study of psychopathology among soldiers who presented to an ED. PMID: 30221870 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
This study seeks to determine the alternations of metabolites in the bilateral anterior cingulate cortex (ACC) of CD patients with abdominal pain by using proton magnetic resonance spectroscopy (1H-MRS) to further explore the neural mechanism.MethodsSixteen CD patients with abdominal pain and 13 CD patients without abdominal pain, were recruited alongside 20 healthy controls (HCs) for this study. Clinical evaluations, including the 0–10 Visual Analogue Scale (VAS) of pain, Hospital Anxiety and Depression Scale (HADS) and Crohn's Disease Activity Index (CDAI), were evaluated prior to MR scanning. This study selected t...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusion: The results confirm the hypotheses that probiotic supplement might help stable individuals with BD to improve the cognitive function, which in turn might lead to better psychosocial, occupational, work and financial functioning. Nevertheless, the idea of this potential new treatment is challenging because of the variety of the human ’s gut microbiota.Neuropsychobiology
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
I'm pleased to note that the Methuselah Fund has closed its first fundraising effort after hitting the target amount, obtaining the support of many long-standing members of our community. The fund is a mixed for-profit/non-profit vehicle that is intended to expand the investment efforts undertaken by the Methuselah Foundation in past years, helping promising lines of rejuvenation research to make the leap from laboratory to commercial development. At the present point in time there are few enough rejuvenation focused companies that doing this well requires extensive connections within the research community, and a willingn...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
Traveling abroad can be exhilarating. But sometimes it’s easy to discount the crippling jet leg that can set in after traversing multiple time zones—leaving you exhausted, disoriented and possibly causing you to miss out on your vacation. Jet lag is “something that can ruin a vacation or plague athletes and musicians or have a businessman or woman not perform at their peak,” explains Charmane Eastman, a professor in the Department of Behavioral Sciences and the founding director of the Biological Rhythms Research Laboratory at Rush University Medical Center in Chicago. The number of passengers flyin...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health jet lag Living sleep Travel Source Type: news
Over the last 50 years, researchers have made “transformative” advances in understanding how the brain works. But there haven’t been corresponding breakthroughs in psychiatric drugs.
Source: WebMD Health - Category: Consumer Health News Source Type: news
The original version of this article unfortunately contained a mistake in Fig.  1. The figure was incorrectly presented with the results of an additional path model for forgotten antiretroviral therapy (ART) doses that was dropped from the primary analyses.
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
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