Thyroid Function Screening in Children With Alopecia Areata —Reply
In Reply We appreciate the interest of Drs Rustagi and Weiss in our proposed screening guidelines for thyroid function in children with alopecia. We have noted that many blood tests are performed in children with alopecia areata who have no symptoms outside of their hair loss, and so the goal of our article was to suggest a reduction in the number of patients who are being screened for thyroid disease when they present with alopecia areata. We stand by our conclusions that the specific subpopulation of patients who have both alopecia areata and trisomy 21 should undergo thyroid screening at the occurrence of new-onset alopecia areata if they have not had recent screening. The association between Down syndrome and thyroid disorders is well recognized, and patients with Down syndrome have an increased prevalence of both congenital hypothyroidism and acquired thyroid dysfunction, with hypothyroidism being most common. The American Academy of Pediatrics recommends screening at age 6 months, age 12 months, and annually thereafter or at the development of new symptoms. We found a statistically significant association between Down syndrome in patients with alopecia areata who also had thyroid abnormalities.
This study aimed at determining if first trimester serum biomarkers could predict adverse pregnancy outcomes associated with villitis (VUE) and chronic intervillositis of unknown etiology (CIUE).Study designBetween January 2013 and June 2018, we selected from pathology department files placentas with VUE or CIUE associated with VUE and control placentas with available first trimester Down syndrome screening results. First trimester PAPP-A and βhCG levels were recorded. Placental growth factor (PlGF) levels were measured in patients with an available first trimester serum sample. Histological findings in placentas, cou...
Authors: Esfandiari N, Reyes-Gastelum D, Hawley ST, Haymart MR, Papaleontiou M Abstract BACKGROUND: Levothyroxine is one of the most commonly prescribed medications in the United States. Although prior research focused on over- and undertreatment and patient dissatisfaction with thyroid hormone, little is known about physician reported barriers to managing thyroid hormone therapy. Additionally, the impact of patient requests for tests and treatments on hypothyroidism management remains unexplored. METHODS: We randomly surveyed physician members of the Endocrine Society, American Academy of Family Practice and A...
While scalp alopecia represents a distinctive feature of chronic graft-versus-host disease (cGVHD), little is known about the clinical and histological presentation of hair loss.
Publication date: Available online 13 June 2019Source: Canadian Journal of DiabetesAuthor(s): Nancy Cardinez, Christine Opsteen, Bruce A. Perkins
Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-oncogenic L-thyroxine (T4) from pro-metabolic 3,5,3’-triiodo-L-thyronine (T3) has enabled clinical implementation whereby exogenous T3 may replace exogenous (or endogenous) T4 to maintain clinical euthyroid hypothyroxinemia that results in significantly better survival in advanced cancer patients without the morbidity of clinical hypothyroidism.
Down syndrome (DS) remains the most common chromosomal disorder with the incidence of 1 in 700 babies in the United States. Down's syndrome increases the risk of respiratory and congenital heart defects and therefore, increasing the need for extra life support.1 Without surgery, congenital heart disease is a major source of morbidity and premature death. The life expectancy of individuals with Down's syndrome without any congenital heart defects is 60-70 years of age.2 However, patients with congenital heart defects have five times higher risk of death as compared to people without any congenital defects.
This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT. Material and Methods: This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu. Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC. Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis. All the data were tabulated. Results and Discussion: Of the 212 patients who...
Conclusion: Choosing an optimal time for levothyroxine intake during the month of Ramadan remains a challenge. The current study did not provide any evidence on ideal time and dose of levothyroxine administration during fasting to manage hypothyroidism. Studies with a larger number of patients need to be done to further explore this issue. PMID: 31428148 [PubMed]
This case report describes the development of alopecia following an injection of deoxycholic acid for treatment of submental adiposity.