Comparative study of the effects exerted by N-Valproyl-L-Phenylalanine and N-valproyl-L-tryptophan on CA1 hippocampal epileptiform activity in rat.

CONCLUSIONS: Both VPA-Phen and VPA-Tryp exert significant inhibitory effects on hippocampal burst activity parameters. Although of comparable magnitude, VPA-Phen-dependent effects have shorter duration than VPA-Tryp-induced ones. Nevertheless, the present results confirm that the conjugation between VPA and aminoacids represents a valid tool to improve the efficacy of antiepileptic drugs and, as well as for VPA-Tryp, propose VPA-Phen as a novel VPA derivative with enhanced pharmacological features Highlights - Effects of VPA-Phen and VPA-Tryp on CA1 epileptiform bursting activity were compared - 0.2, 0.5 and 1 mM drug concentrations were used in rat brain slices - Both VPA-Phen and VPA-Tryp reduced epileptiform burst rate and duration - VPA-Phen-induced effect were significantly shorter than the VPA-Tryp-induced ones. PMID: 29629658 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research