Role of Mechanotransduction in Thoracic Aortic Aneurysms and Acute Aortic Dissections

Date: Tuesday, 05 22, 2018; Speaker: Dianna McGookey Milewicz, MD, PhD, Director, Division of Medical Genetics, University of Texas Health Science Center at Houston; Building: Building 50; 1227/1233
Source: NIH Calendar of Events - Category: American Health Source Type: events

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With a focus on renal function, the goal of this multicentre study was to assess peri-operative complications and late mortality of open surgical repair (OSR) of juxtarenal abdominal aortic aneurysms (JRAAA).
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Publication date: Available online 12 September 2019Source: The Annals of Thoracic SurgeryAuthor(s): Akiko Tanaka, Zain Al-Rstum, Samuel D. Leonard, Bri’Ana D. Gardiner, Ibrahim Yazij, Harleen K. Sandhu, Charles C. Miller, Hazim J. Safi, Anthony L. EstreraABSTRACTBackgroundWe reviewed the efficacy of intraoperative intercostal nerve cryoanalgesia for pain control in patients undergoing descending and thoracoabdominal aortic aneurysm (D/TAAA) repairs.MethodsDuring 2013 and 2017, 241 patients underwent D/TAAA repair. Of those, 38 were treated with intraoperative cryoanalgesia to the intercostal nerves at the level of f...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ub NL Abstract Perivascular adipocytes residing in the vascular adventitia are recognized as distinct endocrine cells capable of responding to inflammatory stimuli and communicating with the sympathetic nervous system and adjacent blood vessel cells, thereby releasing adipocytokines and other signaling mediators to maintain vascular homeostasis. Perivascular adipocytes exhibit phenotypic heterogeneity (both white and brown adipocytes) and become dysfunctional in conditions, such as diet-induced obesity, thus promoting vascular inflammation, vasoconstriction, and smooth muscle cell proliferation to potentially cont...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Conclusions: Nearly half of rAAA patients have a door-to-intervention time longer than recommended societal guidelines. Sex differences in mortality after rAAA repair seem to be driven by in-hospital treatment delays.
Source: Annals of Surgery - Category: Surgery Tags: PAPERS OF THE 139TH ASA ANNUAL MEETING Source Type: research
Authors: Bennett AC, Bennett CL, Witherspoon BJ, Knopf KB Abstract Introduction: Ciprofloxacin, levofloxacin, and moxifloxacin belong to the fluoroquinolone class of antibiotics and are amongst the most commonly prescribed antibiotics. In 2018 and 2019, Food and Drug Administration (FDA) and the European Medicine Agency (EMA) requested that manufacturers harmonize FQ safety information related to neuropsychiatric, aortic dissection, and long-term disability. The authors hypothesize that FDA and EMA epidemiologists support a strong association between these drugs and the three toxicities. Areas covered: Studies of F...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Condition:   Abdominal Aortic Aneurysm Intervention:   Procedure: Endovascular repair or Open surgery Sponsor:   Hospital Sao Joao Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The role of Non-POU-domain-containing octamer-binding protein (NONO) in the formation and development of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) in apolipoprotein E-knockout (ApoE-/- ) mice is still unknown. In Part I, the protein level of NONO was suggestively greater in the AAA tissues compare to that in the normal abdominal aortas. In Part II, 20 ApoE-/- male mice were used to examine the transfection efficiency of lentivirus by detecting GFP fluorescence. In Part III, mice were arbitrarily separated into two groups: one was the control group without Ang II infusion, and another...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
New England Journal of Medicine,Volume 381, Issue 11, September 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research
A 55-year-old man with schizophrenia, and recent open abdominal aortic aneurysm repair was admitted for new abdominal pain. The abdominal aortic aneurysm repair had been complicated by the development of intraabdominal abscesses, which had been treated with antibiotics and drainage and the patient was discharged. Three days later he presented to the Emergency Department for new abdominal pain. On presentation, the patient was agitated and combative with providers. He reported “total body pain” and abdominal pain.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Patients older than 80  years have significantly lower early mortality with endovascular aneurysm repair (EVAR) compared with open repair for abdominal aortic aneurysms (AAAs), but long-term results remain poorly studied. We analyzed the results of both emergent and elective AAA repair in patients aged 80 years or older who had at least 5 years of follow-up.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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