Dementia: This common drug increases dementia risk by up to 60 percent

A DRUG that is widely used to treat epilepsy and bipolar disorder in the UK has been found to increase the risk of dementia by up to 60 percent by breaking down brain cells.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Last year, Molecular Brain became the first BMC journal to introduce Micro Reports, an innovative way to quickly share research which would otherwise go unpublished as a full research paper. Micro Reports are short research summaries of up to 1200 words, ideal for publishing negative results, reproduced studies, smaller data sets which are still important but would not warrant a full research article, and brand new findings which should enter the public domain as soon as possible. Since the launch of this new article type, the journal has received 58 Micro Report submissions, with 24 publications to date. We’ve highl...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Open Access Publishing Molecular Brain neuroscience SfN19 Source Type: blogs
Preoperative and postoperative mental health status (MHS) of total joint arthroplasty patients can affect immediate and long-term outcomes following surgery. Alterations in MHS can be acute or chronic. The most common etiologies include acute changes due to (1) delirium or stroke, (2) movement disorders (Alzheimer dementia, Parkinson disease, multiple sclerosis, epilepsy), and (3) mood/behavior disorders (major depressive disorder, anxiety, bipolar disorder, schizophrenia). Across etiologies, alterations in MHS are associated with worse clinical/patient-reported outcomes and greater total cost of care. Prevention via pharm...
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders Ela Austria Barcelon1,2*, Takahiko Mukaino1, Jun Yokoyama1, Taira Uehara2, Katsuya Ogata2, Jun-ichi Kira1 and Shozo Tobimatsu2 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan2Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: 2018Source: International Review of Neurobiology, Volume 139Author(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors (placebo respo...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 2 August 2018Source: International Review of NeurobiologyAuthor(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Published papers usually need a large amount of additional data to support and strengthen the main “striking” finding and conclusions. If this research is the lab’s main focus this causes no issues. However, pieces of interesting data off the mainstream topic of the lab can often be found in the research process. In this situation, we may recognize the potential importance of the result, but the volume of the work needed to publish it could be overwhelming and sufficient enough to stop publication of the finding. This data is then placed on the shelf and is forgotten without being seen by others. But, wha...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Open Access Publishing animal model Molecular Brain neurodegeneration neurodegenerative disease neurology neuroscience reproducibility Source Type: blogs
In this study, we exam...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Micro report Source Type: research
The Middle East and North Africa (MENA) face daunting challenges in managing a growing burden of mental illness, often in adverse conditions that can leave their imprint on generations to come.While the burden of mental-health conditions is above the global average in most MENA countries, the human resources, policies, funding and infrastructure to deal with these problems are sorely lacking.According to a recent study led by the Institute for Health Metrics and Evaluation (IHME), mental disorders excluding substance abuse accounted for 4.7% of all disability-adjusted life years (DALYs) in the World Health Organization &rs...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
We present the case of an 80-year-old woman, single with no children, who lived alone, and, up until presentation, was able to perform activities of daily living self-sufficiently. She reported to have the support of friends and neighbors, and she lived in the small community of São Miguel Island, Azores, Portugal. She had completed two years of college before dropping out during her third year, and her last job was as an elder care-worker. She had no personal or family psychiatric antecedents and no history of alcohol or illicit drug addictions. The patient was diagnosed with DM2 two years previously and was treate...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue acute confusional state delirium diabetes hyperglycemia psychosis Source Type: research
Valproic acid has been used in the treatment of epilepsy, bipolar and schizoaffective disorder, dementia-related agitation and neuropathic pain effectively. However, it can elevate blood ammonia levels, which might lead to clinically significant situations such as hyperammonemic encephalopathy. Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite therapeutic doses and serum levels of VPA.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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