Novel hormone replacement therapy trial demonstrates improved memory function in adrenal patients

Better timing for cortisol replacement therapies, to more closely replicate the secretion patterns of people with normal levels of the hormone, has shown a significant improvement in patients' cognitive function. This is the striking finding from a new trial led by University of Bristol scientists including Professor Stafford Lightman and published in the Proceedings of the National Academy of Science (PNAS). The findings are potentially important and underline the case for novel therapeutic approaches, as patients on cortisol replacement therapy often have side effects that make it difficult for them to lead normal lives.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School; Press Release Source Type: news

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Contributors : Eric M Blalock ; Yasir AlSiraj ; Sean E Thatcher ; Ryan Temel ; Lei Cai ; Wendy Katz ; Heba M Ali ; Michael Petriello ; Andrew Morris ; Arthur P Arnold ; Karen Reue ; Patrick Tso ; Lisa CassisSeries Type : Expression profiling by arrayOrganism : Mus musculusIt is well recognized that men and women differ in circulating lipid profiles and consequently coronary artery disease (CAD). While sex hormones like estrogens are thought to protect women from CAD risk by promoting protective lipid profiles, hormone replacement therapy in women paradoxically increases CAD risk. Biological sex is determined by both sex ch...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 15 April 2019Source: International Journal of PharmaceuticsAuthor(s): I. Koutsamanis, S. Eder, M. Beretta, A. Witschnigg, A. Paudel, K. Nickisch, M. Friedrich, K. Eggenreich, E. RobleggAbstractThe application of ethylene-vinyl acetate (EVA) copolymers in reservoir-type intra-vaginal rings (IVRs) offers advantages over silicones including i) versatile properties, ii) absence of curing chemistry, and iii) continuous and flexible processing via co-extrusion. Thus, we investigated the capability of EVA based IVRs to deliver broad ranges of estradiol (E2) thereby, fulfilling the requirements o...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsExtracted rat pituitary gland supplemented with special preservation solution could be preserved for 3  days under hypothermic condition.
Source: Pituitary - Category: Endocrinology Source Type: research
A 49 year old surgically menopausal female on hormone replacement therapy presented to our clinic with persistent abdominal pain, pelvic pressure, nausea, and vomiting. She had history of severe endometriosis with prior total abdominal hysterectomy and bilateral salpingo-oophorectomy (BSO) performed at an outside facility. Significant bowel adhesions were encountered intra-operatively and the endometriosis was incompletely excised. A pelvic MRI at our institution demonstrated a nodular lesion in the sigmoid colon measuring 15  × 11mm impressing upon the wall of the colon resulting in luminal narrowing over a leng...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Original Article Source Type: research
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract PURPOSE OF REVIEW: Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies. RECENT FINDINGS: Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Close hemodyna...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Hormone replacement therapy is associated with a small but significantly increased risk of Alzheimer ’s disease, research published in The BMJ has found
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
AbstractTraumatic brain injury (TBI) causes substantial neurological disabilities and mental distress. Annual TBI incidence is in magnitude of millions, making it a global health challenge. Categorization of TBI into severe, moderate and mild by scores on the Glasgow coma scale (GCS) is based on clinical grounds and standard brain imaging (CT). Recent research focused  on repeated mild TBI (sport and non-sport concussions) suggests that a considerable number of patients have long-term disabling neurocognitive and neurobehavioral sequelae. These relate to subtle neuronal injury (diffuse axonal injury) visible only by u...
Source: Pituitary - Category: Endocrinology Source Type: research
The platform's new group can help users track hormone replacement therapy and other specific health needs while connecting patients to care.
Source: mobihealthnews - Category: Information Technology Source Type: news
CONCLUSION Organ shortage remains a growing problem in the United States. Donor management including HRT has been proposed to combat the endocrine derangement associated with brain death and, in particular, TBI. While the existing literature reported compelling outcomes using HRT, there remains a need for further Level I and Level II evidence studies to define optimal practice. LEVEL OF EVIDENCE Review article, level IV.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: REVIEW ARTICLES Source Type: research
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