Investigation of possible risk factors for depression in Alzheimer's disease: A systematic review of the evidence

Alzheimer's disease (AD) is the most common form of dementia and a leading cause of disability in late life (Prince  et al., 2013). Despite cognitive symptoms being the hallmark of the disease, depression is common affecting around half of patients at some point during the illness (Di Iulio et al., 2010). Systematic review data (Chi et al., 2015) indicate that estimates of prevalence of major depression in Alzheimer's disease vary by diagnostic approaches, with estimates of 12.7% using DSM-IV criteria (American Psychiatric Association, 1994), versus rates of over 40% in studies employing criteria specific to AD (NIMH-dAD; National Institute of Mental Health – depression in AD; Olin et al., 2002) .
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research