Comparison of the long-term treatment outcomes of women and men diagnosed with schizophrenia over a period of 20  years

Numerous studies into the differences in course of schizophrenia between women and men produce contradictory results. Few research teams undertook long-term prospective observations.
Source: Comprehensive Psychiatry - Category: Psychiatry Authors: Source Type: research

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ConclusionsDifferential changes are found in astrocyte and microglia genes in PFC subregions in relation to schizophrenia and suicide, indicating possible disturbances of glia homeostasis in these conditions.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 9 November 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Julio Rodriguez-López, Manuel Arrojo, Eduardo Paz, Mario Páramo, Javier CostasAbstractGenetic risk for schizophrenia is due to the joint effect of multiple genes acting mainly at two different processes, prenatal/perinatal neurodevelopment and adolescence/early adulthood synapse maturation. Identification of important genes at the second process is of relevance for early intervention. The aim of this work was to identify gene co-expression modules with altered expression in schizo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Discussion of the importance of the use of manualized treatment protocols in dance/movement therapy research and their limitations follows.
Source: American Journal of Dance Therapy - Category: Complementary Medicine Source Type: research
Schizophrenia is a chronic psychotic disorder with a lifetime prevalence of about 1%. Onset is typically in adolescence or early adulthood; characteristic symptoms include positive symptoms, negative symptoms, and impairments in cognition. Neuroimaging studies have shown substantive evidence of brain structural, functional, and neurochemical alterations that are more pronounced in the association cortex and subcortical regions. These abnormalities are not sufficiently specific to be of diagnostic value, but there may be a role for imaging techniques to provide predictions of outcome. Incorporating multimodal imaging datase...
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
Publication date: Available online 8 November 2019Source: Trends in Pharmacological SciencesAuthor(s): Sean P. Moran, James Maksymetz, P. Jeffrey ConnMuscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several brain disorders. Recent advances in the discovery of subtype-selective allosteric modulators for mAChRs has provided an unprecedented opportunity for highly specific modulation of signaling by individual mAChR subtypes in the brain. Recently, mAChR allosteric...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
ConclusionThe prevalence of SD is high in SZ subjects. In addition to the current guidelines, the present review suggests that treating depressive symptoms may be a major intervention to improve SD in SZ subjects. Sociodemographic variables, physical illnesses, metabolic syndrome and peripheral inflammation have been poorly or never explored and should be included in future studies.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 9 November 2019Source: Neuroscience LettersAuthor(s): Najate Benamer, Marie Vidal, Maria Cecilia AnguloABSTRACTIn the cerebral cortex, GABAergic interneurons and oligodendrocyte lineage cells share different characteristics and interact despite being neurons and glial cells, respectively. These two distinct cell types share common embryonic origins and are born from precursors expressing similar transcription factors. Moreover, they highly interact with each other through different communication mechanisms during development. Notably, cortical oligodendrocyte precursor cells (OPCs) receiv...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In this study, we recruited 34 patients with MDD, 77 patients with SCZ and 65 healthy control (HC) subjects to clarify the circulating BDNF levels in MDD and SCZ patients, and to assess whether serum BDNF levels were associated with the disease severity. Our results showed that serum BDNF levels were significantly decreased in the patients with SCZ (Mean difference = -4.517, 95%CI of difference = -7.854 to -1.180, p 
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 8 November 2019Source: Meta GeneAuthor(s): Ali Molaei, Zahra Noormohammadi, Iman Salahshourifar, Niloufar Mahdavi HezavehAbstractSchizophrenia (SCZ) is a complex chronic brain disorder. The brain-derived neurotrophic factor (BDNF) is a member of the neurotrophins family, which plays a role in neuron proliferation. In the present work, we aimed to 1- Provide evidence on the association of BDNF variants and Schizophrenia, and 2- Investigate the association between MIR-204 with BDNF. We investigated the association between single-nucleotide changes in rs112062096 of MIR-204 and rs11030099 in...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
PURPOSE: The therapeutic effects of outdoor cycling (OC) and its benefits on physical activity (PA) were investigated in people with schizophrenia. METHODS: Sixty patients with schizophrenia were randomly assigned to 16-weeks of Outdoor Cycling (OC...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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