172. Receptor Protein Tyrosine Phosphatases in Schizophrenia

Receptor protein tyrosine phosphatases, gamma (PTPRZ) and zeta (PTPRG), are cell surface ligands for contactin molecules, they bind with Contactins and are crucial for cell adhesion, signaling and neurodevelopment. Their main expression is in microglia and neurons, respectively; PTPRZ is essential for recovery from neuroinflammation. Both regulate neurotransmitter receptor function and are genetically associated with schizophrenia, affective disorders, Alzheimer ’s and autism.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research