262. Human Dg-Seq Reveals Cell-Type-Specific Effectors of Schizophrenia Risk

The granule cell layer of the Dentate Gyrus (DG-GCL) is an unusually homogeneous cell population. Previous findings linking this important cell type to bipolar disorder and schizophrenia used animal models, induced pluripotent stem cell (iPSC), or low-resolution functional imaging. We therefore sought to isolate and characterize human DG-GCL neurons to better characterize their role in psychiatric disorders.

Source: Biological Psychiatry - April 8, 2018 Category: Psychiatry Authors: Daniel Hoeppner, Andrew Jaffe, Joy Ukaigwe, Lou Blanpain, Ran Tao, Ronald McKay, Mitsuyuki Matsumoto, Joel Kleinman, Daniel Weinberger, Thomas Hyde Tags: SYMPOSIUM Source Type: research