265. Electrophysiological Measurements of DG Neurons Derived From Bipolar Disorder and Schizophrenia Patients

The study of psychiatric disorders was limited by the paucity of adequate models. These disorders are genetically complex, with many candidate-associated genes. Due to this genetic complexity, animal models that were developed did not recapitulate most of the phenotypes associated with the disorders. The introduction of induced pluripotent stem cells (iPSCs) allowed measurement of cellular phenotypes for psychiatric disorders.

Source: Biological Psychiatry - April 8, 2018 Category: Psychiatry Authors: Shani Stern, Maria Carol Marchetto, Renata Santos, Meiyan Wang, Anne Bang, Martin Alda, Fred Gage Source Type: research