Depressive symptoms and suicidal ideation among symptomatic patients with a history of Lyme disease vs two comparison groups - Doshi S, Keilp JG, Strobino B, McElhiney M, Rabkin J, Fallon BA.

BACKGROUND: Depression has been reported in 8-45% of patients with posttreatment Lyme symptoms (PTLS), but little is known about suicidal ideation in these patients. METHOD: Depression and suicidal ideation were assessed using the Beck Depression I...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

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In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 25 May 2019Source: Journal of Anxiety DisordersAuthor(s): Bunmi O. Olatunji, Jingu Kim, Rebecca C. Cox, Chad EbesutaniAbstractAlthough considerable evidence has linked disgust proneness (DP) to obsessive-compulsive disorder (OCD), few studies have examined the extent to which DP predicts OCD symptoms over time. Further, it remains unclear if DP is a risk factor for the contamination subtype of OCD specifically or if it is prospectively associated with other OCD symptom subtypes. The present study sought to address these gaps in the literature with a large sample of unselected community pa...
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Depression has been reported in 8 –45% of patients with post-treatment Lyme symptoms (PTLS), but little is known about suicidal ideation in these patients.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Source Type: research
Depression has been reported in 8 –45% of patients with posttreatment Lyme symptoms (PTLS), but little is known about suicidal ideation in these patients.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Tags: Original Research Report Source Type: research
PURPOSE: The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject. INTRODUCTION: Multiple case reports and...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
Someone in recovery circles once told me that if you have one foot in the past and another in the future, you are essentially peeing on the present. I try to remember that when I’m engulfed in regret — obsessing about all the things I did wrong in the past and wishing to God I had made different decisions. However, writing about my mistakes has always been healing for me because I’d like to think this small action could possibly prevent someone else from making the same ones. If I can help a young person or anyone who has recently been diagnosed with depression take a more direct route to healing, it seem...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Medications Mental Health and Wellness Motivation and Inspiration Personal Psychiatry Stress Suicide Treatment Bipolar Disorder Depressive Episode Epigenetics Major Depressive Disorder Melancholy Neuroplasticity Sa Source Type: blogs
Spring is in the air a little earlier this year, but don’t go celebrating just yet. This year’s weather is shattering norms. Washington, D.C., for example, not only had the warmest February on record, but last month’s temps already surpassed the average records for March, too. The situation is similar for a lot of other spots across the country, and that could be bad news when it comes to public health. Experts theorize climate change may be part of the cause of this year’s early spring phenomenon, and warn the overall warming of the planet can have physical and mental health consequences....
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
I just had a flashback. When I was diagnosed with Lyme, I knew little about it. I went to the first infectious disease doctor with my bullseye still present, asking lots of questions. Among them, are you sure this three weeks of doxycycline is enough. He smiled, and with his eyes fixed on his computer, he said, "Yes, it's more than enough. In fact, I could just tell you to take ten days but then you'd come back later if anything went haywire and ask why I didn't give you twenty-one." He looked up, "Call me if anything goes crazy." A month later, I called. I woke up with a very sore throat and fever two ...
Source: Science - The Huffington Post - Category: Science Source Type: news
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