Mortality and morbidity in patients with osteogenesis imperfecta in Denmark.

Conclusion: The all-cause hazard ratio for premature death in OI was 2.9 compared to the reference population. There was an increased risk of death due to respiratory diseases, gastrointestinal diseases and death following trauma. 
2) Study 2 aimed to compare the fracture rates across the lifespan of patients with OI with that of the general population. Using a nationwide, registry-based, cohort study design, we counted all fractures registered from 1995 in the National Patient Register. The study included the same population as in study 1, but patients who died before 1995 were excluded. We identified 644 patients
 
(55.6% females) in the OI cohort through the Danish National Patient Register and 3,361 persons (55.2% females), randomly selected from the Civil Registry System. A total of 416 patients with OI experienced a total of 1,566 fractures during the observation period of median 17.9 years (IQ-range: 12.4-18.0), adding up to 10,137 person years. In comparison, 709 persons in the reference population experienced a total of 1,018 fractures during follow-up. Both male and female patients with OI had an increased fracture rate throughout their life. The fracture rate ratio for participants aged 0-19 years was 10.7, for participants aged 20-54 years 17.2, and for participants aged 55 years and over 4.1 when compared to the reference population. The highest fracture rate was seen in males with OI aged 0-19 years (257 fractures per 1,000 person years). The fractures app...
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research