Prevalent Homozygous Deletions of Type I Interferon and Defensin Genes in Human Cancers Associate with Immunotherapy Resistance.

CONCLUSIONS: Our analysis reveals that the homozygous deletion of interferon and defensin genes are prevalent in human cancers, and importantly this feature can be used as a novel prognostic biomarker for immunotherapy resistance. PMID: 29618619 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29618619?dopt=Abstract

Source: Clinical Cancer Research - April 4, 2018 Category: Cancer & Oncology Authors: Wang L, Ye Z, Dong H, Li Y, Ma T, Huang H, Leong HS, Eckel-Passow JE, Kocher JP, Liang H Tags: Clin Cancer Res Source Type: research