Mass. Eye and Ear aims to test abortion drug as treatment for brain tumor

Massachusetts Eye and Ear researchers hope to launch mid-stage trials of a drug commonly used to induce chemical abortion, called mifepristone, to treat a rare type of brain tumor. Researchers had been looking for a drug to treat the growth of a potentially lethal brain tumor called vestibular schwannoma. The cancer usually causes hearing loss and tinnitus, but can also cause dizziness and facial nerve paralysis. Because of where such tumors grow – often on the vestibular, or balance, nerve —…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. BlackSummaryProtein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzyme...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. QuezadaSummaryThe immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting co...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. ParishSummaryEscape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin ligase activator, NDFIP1, enforces a cell-intrinsic CD8+ T cell checkpoint that desensitizes TCR signaling during in vivo exposure to high antigen levels. Ndfip1-deficient OT-I CD8+ T&...
Source: Cell Reports - Category: Cytology Source Type: research
MIDNIGHT fridge raiders are more at risk of developing breast or prostate cancer, research revealed last night.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Comorbidities have a negative prognostic impact on overall survival in cancer patients, and should be assessed as risk factors for mortality when reporting outcomes. PMID: 30012908 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
Publication date: Available online 17 July 2018Source: The Annals of Thoracic SurgeryAuthor(s): Ju-Dong Li, Zi-Long Xiao, Xiao-Xiang Hou
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: Given the performance of the PBIC, it would be highly appropriate to use the device for therapeutic infusions in human clinical trials to assess its capability for large-volume infusions.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
People who eat dinner before 9 p.m. -- or at least two hours before going to sleep -- have a 20% lower risk of breast and prostate cancer than those who eat after 10 p.m. or go to bed shortly after supper, researchers found.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Source: Journal of Biopharmaceutical Statistics - Category: Statistics Authors: Source Type: research
BOWEL cancer symptoms and signs may be subtle, making them hard to spot. It is important to check for the cancer, however, as it is one of the most common in the UK. Seeing this in the toilet bowel could be a sign of the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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