UCLA scientists discover that cells contain mitochondria specialized to build fats

Mitochondria, known to most people as the “powerhouses of the cell,” have been recognized for decades as the cellular organelle where sugars and fats are oxidized to generate energy. Now, new research by UCLA scientists has found that not all mitochondria fit this definition. Within each cell a group of specialized mitochondria can be f ound attached to fat droplets. Rather than burn fat to create energy, these specialized mitochondria are responsible for providing the energy to build and store fat molecules.“This is really a whole new view of mitochondria and what they can do,” said lead author Dr. Orian Shirihai, a professor of medicine in endocrinology and pharmacology at the David Geffen School of Medicine at UCLA. The finding,published in Cell Metabolism, may one day lead to new treatments for obesity, fatty liver and other metabolic diseases, he added.Mitochondria, small organelles that are present by the hundreds or thousands inside many types of cells, contain the molecular machinery for producing ATP, the molecule that stores energy in cells. Mitochondria within any given cell have always been considered uniform, said Shirihai, because they constantly merge and separate with each other in processes known as “fusion” and “fission,” respectively.In the past, researchers have noticed — when looking at cells under a microscope — that some mitochondria associate with lipid droplets, small clumps of fatty molecule...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: Life Sciences - Category: Biology Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 22 October 2018Source: Science &SportsAuthor(s): M. Mogharnasi, A. TajiTabas, M. Tashakorizadeh, S.H. NayebifarSummaryObjectivesNesfatin-1 and HSP70 are involved in the regulating mechanisms of insulin and glucose metabolism. The aim of this study was to evaluate the effects of 10 weeks of resistance and endurance exercise training on the serum levels of nesfatin-1, HSP70 and insulin resistance (IR) in women with type 2 diabetes.Materials and Methods26 women with type 2 diabetes were selected using purposive sampling and were randomly divided into three groups...
Source: Science and Sports - Category: Sports Medicine Source Type: research
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Source: NeuroImage: Clinical - Category: Radiology Source Type: research
October 23, 2018Rosaura guides her clients through a challenging health system during the most vulnerable moments in their lives.Last week I shadowed Rosaura Polanco, a community health worker in the South Bronx in New York City, where she provides underserved women with health education and essential health services. Having only seen examples of community health workers operating in sub-Saharan Africa, I asked Rosaura what unites them around the world, despite their differing roles and contexts.“Empathy,” she replied. “I practice empathy, for everything, all the time.”Rosaura works forGrameen Prima...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
Conclusion: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet‐induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. (Hepatology 2017).
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
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Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
Conclusions: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet‐induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: NHS News Feed - Category: Consumer Health News Tags: Diabetes Medication Obesity Source Type: news
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