UCLA scientists discover that cells contain mitochondria specialized to build fats

Mitochondria, known to most people as the “powerhouses of the cell,” have been recognized for decades as the cellular organelle where sugars and fats are oxidized to generate energy. Now, new research by UCLA scientists has found that not all mitochondria fit this definition. Within each cell a group of specialized mitochondria can be f ound attached to fat droplets. Rather than burn fat to create energy, these specialized mitochondria are responsible for providing the energy to build and store fat molecules.“This is really a whole new view of mitochondria and what they can do,” said lead author Dr. Orian Shirihai, a professor of medicine in endocrinology and pharmacology at the David Geffen School of Medicine at UCLA. The finding,published in Cell Metabolism, may one day lead to new treatments for obesity, fatty liver and other metabolic diseases, he added.Mitochondria, small organelles that are present by the hundreds or thousands inside many types of cells, contain the molecular machinery for producing ATP, the molecule that stores energy in cells. Mitochondria within any given cell have always been considered uniform, said Shirihai, because they constantly merge and separate with each other in processes known as “fusion” and “fission,” respectively.In the past, researchers have noticed — when looking at cells under a microscope — that some mitochondria associate with lipid droplets, small clumps of fatty molecule...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Publication date: Available online 16 August 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Chen Chi, Dong-Jie Li, Yu-Jie Jiang, Jie Tong, Hui Fu, Yi-Hang Wu, Fu-Ming ShenAbstractAging is a worldwide challenge, and it is accompanied by the accumulation of senescent cells. Cellular senescence is traditionally defined as permanent cell growth arrest and currently includes the senescence-associated secretory phenotype (SASP). There are two main types of cellular senescence, including telomere-dependent replicative senescence and stress-induced premature senescence. The process of cellul...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
In this study, we tested whether catalpol has the potential to improve insulin sensitivity by augmenting myogenesis.Main methodsWe examined the hypoglycaemic mechanism of catalpol in db/db mice and C2C12 cells. db/db mice were treated with catalpol (200 mg/kg) for 8 consecutive weeks. Serum analysis, skeletal muscle performance and histology, and gene and protein expression were performed. In vitro glucose uptake, gene and protein expression were determined, and small interfering RNA was used to identify the underlying hypoglycaemic mechanism of catalpol.Key findingsIn this study, we tested whether catalpol has the poten...
Source: Life Sciences - Category: Biology Source Type: research
People with type 2 diabetes can significantly reduce cardiovascular disease risk with proper treatment and not smoking, according to a study in Sweden.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Publication date: Available online 16 August 2018Source: Revista Clínica Española (English Edition)Author(s): J. Montes-Santiago
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Resumo O objetivo deste artigo é medir a prevalência e identificar fatores associados à dor lombar intensa (DL intensa) entre parturientes do município de Rio Grande, RS, Brasil, em 2013. Questionário padronizado aplicado por entrevistadoras previamente treinadas em até 48 horas após o parto. Realizou-se análise multivari ável utilizando regressão de Poisson tendo a razão de prevalência como medida de efeito. Dentre as 2685 parturientes incluídas no estudo, 51,2% referiram dor lombar gestacional e 27,3% tinham DL intensa, com maior pro...
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
Conclusion: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet‐induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. (Hepatology 2017).
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
One of the women I work with wanted to know about the new diet drug called Belviq. The FDA is always approving a new “miracle” weight-loss pill, only to recall it a few years later. To date, at least 34 diet drugs have been taken off the market. Diet pills cause all kinds of problems — heart attack, stroke and psychiatric disorders. And Belviq isn’t any different. Some of its side effects include suicidal thoughts, a racing heartbeat, hallucinations and more… The European Union banned Belviq. The reason? It causes cancer in animals.  And here’s the real irony… Clinical tri...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
Conclusions: These data suggest that Fxr and Shp inactivation may be beneficial to combat diet‐induced obesity and uncover that hepatic SHP is necessary to promote fatty liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Sixty-nine percent of Americans adults are overweight, and over 35 percent are obese. Obesity increases your risk for numerous conditions including heart disease, stroke, Type 2 diabetes, high blood pressure, and cancer. Sadly, about 3.4 million adults die each year from being overweight or obese. Globally obesity now kills about the same as tobacco and all wars, terrorism and violence. Nearly all people who are overweight already have "pre-diabetes" and have significant risks of disease and death. They just don't know it. When you begin to put on weight, especially lethal belly fat, your biology shifts out of ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Conclusion This study created a slow release version of DNP, called CRMP, that improved the way the liver processed fat and improved other measures linked to type 2 diabetes risk in rats. It did this when given for up to six weeks without the toxic side effects known to be associated with unmodified DNP. This is encouraging research, which appears to have partially tamed some of the toxic effects of DNP, while protecting its benefits. Researchers will build on this in further studies in rats and possibly people, if these results are confirmed in more studies. However, the current version of DNP that is available for sale ...
Source: NHS News Feed - Category: Consumer Health News Tags: Diabetes Medication Obesity Source Type: news
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