UCLA research could be first step toward healing the hearts of children with Duchenne
After a progressive weakening of the muscles takes away their motor skills, and then their abilities to stand and walk, most males with Duchenne muscular dystrophy die of heart and respiratory failure in their 20s.Now, researchers at theDavid Geffen School of Medicine at UCLA are pursuing a cutting-edge way to stop heart disease in patients with Duchenne, which affects one in 5,000 male babies born in the United States. Their work, which is supported by a David Geffen School of Medicine Seed Grant, is just one of a number of projects underway at the medical school in which interdisciplinary groups of UCLA researchers are pursuing new treatments and cures.The scientists are trying to use minuscule nanoparticles to carry bits of DNA to the hearts of people with Duchenne. Inside heart cells, this new DNA would “trick” the cells’ machinery to reverse the genetic defect. The team is made up of Huan Meng, an assistant professor of nanomedicine; April Pyle, an associate professor of microbiology, immunology and molecular genetics; and Melissa Spencer, a professor of neurology.“Duchenne is such a complicated genetic disease,” Spencer said. “However, because we know the defective gene, recent advances let us directly edit the abnormal gene in muscle and heart cells in vivo.”The complex work is possible because it draws on the researchers ’ varied areas of expertise: Meng’s experience designing drug delivery systems using the latest...
ga JA Abstract This work proposed a procedure for microwave-assisted sample preparation of medicines using diluted nitric acid followed by determination of elemental impurities using inductively coupled plasma optical emission spectrometry (ICP OES) and inductively coupled plasma mass spectrometry (ICP-MS) according to the United States Pharmacopeia Chapters 232 and 233. Three solutions, i.e. inverse aqua regia, 7.0 and 2.0 mol L-1 HNO3, were evaluated for microwave-assisted digestion of nine drugs samples. The applicability of each digestion procedure was assessed by comparison of analyte concentrations deter...
This study systematically reviewed literature examining the influence of the rural built environment on Latinos' health outcomes and behaviour in the United States. A secondary aim of the study was to identify strategies developed to address cha...
CONCLUSIONS: Patient-reported pretreatment sexual function and comorbidities enables stratification and prediction of erectile function. EPIC subset questions with baseline comorbidities may potentially serve as a quick and practical clinical tool for predicting sexual survivorship. PMID: 31005217 [PubMed - in process]
The United States recorded 71 new measles cases last week, a 13 percent increase as the country faces its second-worst outbreak of the disease in almost two decades, federal health officials said on Monday.
Vey Mark G. Ruder Epizootic hemorrhagic disease viruses (EHDVs) are arboviral pathogens of white-tailed deer and other wild and domestic ruminants in North America. Transmitted by various species of Culicoides, EHDVs circulate wherever competent vectors and susceptible ruminant host populations co-exist. The impact of variation in the level and duration of EHDV viremia in white-tailed deer (Odocoileus virginianus) on Culicoides infection prevalence is not well characterized. Here we examined how infection prevalence in a confirmed North American vector of EHDV-2 (Culicoides sonorensis) varies in response to fluctuati...
Gene therapy is effective for CMT in mice, Published online: 23 April 2019; doi:10.1038/s41582-019-0193-1Gene therapy is effective for CMT in mice
There have been 626 cases of measles reported in the United States this year, according to the Centers for Disease Control and Prevention. That's 71 more than the agency reported last week in its weekly update.
(Reuters Health) - Pediatric blood pressure guideline changes issued in 2017 increase the number of children diagnosed with high blood pressure, a new study finds.
Novartis has launched an investigation into the death of an infant participating in a trial for an experimental gene therapy.
The threshold for high blood pressure in children was lowered in 2017. The new standard predicted nearly 20 percent of heart disease cases later in life, a new American Heart Association study found.
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