SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT.

CONCLUSIONS: Taken together, this study unveils a novel mechanism in which SGK1 functions as a tumor metastasis-promoting gene and highlights how co-targeting SGK1 and autophagy restrains cancer progression due to the amplified antimetastatic effects.
PMID: 29609629 [PubMed - in process]

Source: Clinical Prostate Cancer - April 2, 2018 Category: Cancer & Oncology Authors: Liu W, Wang X, Wang Y, Dai Y, Xie Y, Ping Y, Yin B, Yu P, Liu Z, Duan X, Liao Z, Chen Y, Liu C, Li X, Tao Z Tags: J Exp Clin Cancer Res Source Type: research