SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling

ConclusionsOur results indicate that the activation of FAK signaling is critical for proliferation of both imatinib-sensitive and -resistant GIST cells and the interference with FAK/AKT pathway might be beneficial for therapeutic target.

http://link.springer.com/10.1007/s10120-018-0822-1

Source: Gastric Cancer - April 5, 2018 Category: Gastroenterology Source Type: research